Children with acute lymphocytic leukemia in complete remission were randomized between 2 combination chemotherapy schedules for continuation of their remissions. One group received full dosage of 4 antileukemic drugs, and the other received half dosage of the same compounds. Median durations of complete remission and of hematologic remission were longer in the full‐dosage than half‐dosage group. Four out of 21 patients in the full‐dosage group continue in their initial complete remission for 40 to 48 months and have been off treatment for 3 months to 1 year. Nine in the full‐dosage group and 4 in the half‐dosage group remain in continuous hematologic remission for 40 to 55 months. Review of results of previous combination chemotherapy studies of childhood lymphocytic leukemia at this hospital indicated a 17 per cent 5‐year leukemia‐free survival rate.
Seventeen children with acute myelocytic leukemia were treated with a combination of 6‐azauridine, 6‐mercaptopurine, and vincristine. Twelve attained complete bone marrow remission, and 2 achieved good partial remissions. For maintenance therapy, patients who attained remission were randomized into 2 groups: one received 6‐mercaptopurine alone; the other received a combination of 6‐mercaptopurine, 6‐azauridine, and vincristine. The median duration of hematologic remission in these groups was 7 and 6 months, respectively. Meningeal leukemia developed in 8 of 15 patients. The overall median survival time was 8 months; for those who attained remission it was 10.5 months. The combination of 6‐azauridine, 6‐mercaptopurine, and vincristine was effective for remission induction of acute myelocytic leukemia in children.
This circumstance indicates the need for more detailed studies of this disease.The purpose of our study was to determine the incidence of childhood leukemia in MemDr.
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