6-azauridine in combination chemotherapy of childhood acute myelocytic leukemia

Abstract

Seventeen children with acute myelocytic leukemia were treated with a combination of 6‐azauridine, 6‐mercaptopurine, and vincristine. Twelve attained complete bone marrow remission, and 2 achieved good partial remissions. For maintenance therapy, patients who attained remission were randomized into 2 groups: one received 6‐mercaptopurine alone; the other received a combination of 6‐mercaptopurine, 6‐azauridine, and vincristine. The median duration of hematologic remission in these groups was 7 and 6 months, respectively. Meningeal leukemia developed in 8 of 15 patients. The overall median survival time was 8 months; for those who attained remission it was 10.5 months. The combination of 6‐azauridine, 6‐mercaptopurine, and vincristine was effective for remission induction of acute myelocytic leukemia in children.

Heteropolyacides as green and reusable catalysts for the synthesis of [3,4-<i>b</i>][1,3,4] thiadiazines

“…Herein, we wish to report the condensation of 4-amino-6-methyl-3-thioxo-1,2,4-triazine-5(2H)-one (AMTTO) or 4-amino-1,4-dihydro-5-methyle-1,2,4-triazole-5-thione (AMTT) with phenacyl bromide in the presence of sodium ethoxide under refluxing conditions and the use of Keggin type heteroployacids (HPAs), including H 3 [PW 12 The compounds 3 was characterised by NMR, IR spectroscopy and elemental analysis [40]. Compounds 6 was new and its structure was deduced by elemental and spectral analysis.…”

“…Antibacterial [5][6][7] and anti-inflammatory [8], antivirial [9,10], antitumor [11,12], and antifungal [13] activity, as well as interesting CNS depressing activity [14] has been reported for certain of the derivatives. Due to their importance, the synthesis of these compounds is interested for the discovery of improved protocols towards milder and high yielding approaches.…”

Structure-based design, synthesis, molecular docking study and biological evaluation of 1,2,4-triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities

“…The compounds bearing 1,2,4-triazine core have been identified to exhibit a broad spectrum of biological effects, such as antifungal 19 , anti-HIV 20 , adenosine A 2 A receptor antagonist 21 , kinase inhibitor antitumor 22,23 , analgesic 17 , anti-anxiety and antiinflammation effects 24 . As a part of our research program toward the search of potent COX-2 inhibitors with lower side effects, improved affinity and efficacy and dual modes of action, molecular hybridization strategy was employed to design 1,2,4-triazine derivatives.…”

In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells

“…6-Aza analogues of the naturally occurring nucleic acids components represent isosteres with the C-6 carbon atom of the pyrimidine nucleoside base being replaced by nitrogen. 7,8 Certain azanucleosides, 6-azauracil and 6-azacytosine), structurally based on 1,2,4-triazine nucleus have displayed an impressive array of biological activities, among which antitumor, [9][10][11][12][13][14][15][16][17][18][19] antiviral, 20 antimicrobial, 21 antiinflammatory, 22 antiplatelet, 23 antimalarial, 24 and antifungal 25 properties. Additionally, tertiary amines in the linkers reported to be positively charged at physiological pH in order to favor electrostatic interactions in the minor groove with the anionic phosphate DNA backbone.…”