Approximately 1500 active pharmaceutical ingredients are currently in use; however, the environmental occurrence and impacts of only a small proportion of these have been investigated. Recognizing that it would be impractical to monitor and assess all pharmaceuticals that are in use, several previous studies have proposed the use of prioritization approaches to identify substances of most concern so that resources can be focused on these. All of these previous approaches suffer from limitations. In the present study, the authors draw on experience from previous prioritization exercises and present a holistic approach for prioritizing pharmaceuticals in the environment in terms of risks to aquatic and soil organisms, avian and mammalian wildlife, and humans. The approach considers both apical ecotoxicological endpoints as well as potential nonapical effects related to the therapeutic mode of action. Application of the approach is illustrated for 146 active pharmaceuticals that are used either in the community or in hospital settings in the United Kingdom. Using the approach, 16 compounds were identified as a potential priority. These substances include compounds belonging to the antibiotic, antidepressant, anti-inflammatory, antidiabetic, antiobesity, and estrogen classes as well as associated metabolites. In the future, the prioritization approach should be applied more broadly around the different regions of the world. Environ Toxicol Chem 2016;35:1550-1559. © 2016 SETAC.

1. Culture filtrates from Trichoderma viride have been fractionated by gel filtration on Sephadex G-75 followed by ion-exchange chromatography on DEAE- and SE-Sephadex. 2. The components essential for attack on cotton are a carboxymethylcellulase, a cellobiase and a third (C(1)) component which has no action on CM-cellulose, cellobiose or cotton. 3. These components, which together can completely convert cotton into water-soluble products, lose this ability when separated and regain it quantitatively when recombined in their original proportions.

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Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. We cannot determine whether there was a RSL highstand above present on Zanzibar during the mid 2 to lateHolocene. The RSL reconstruction agrees broadly with changes predicted by the ICE-5G geophysical model, which includes 4 m of ice equivalent sea-level rise between 7000 and 4000 cal.yr BP. Our new dating approach has the potential to provide improved chronologies with which to interpret sea level data from this and other mangrove environments.

The occurrence of antibiotic residues in the aquatic environment is an emerging concern. In contrast to daphnia and fish, algae are known to be particularly sensitive to antibiotic exposure. However, to date, a systematic evaluation of the sensitivity of different algal species to antibiotics has not been performed. The aim of the present study was therefore to explore the sensitivity of a battery of algal species toward antibiotic exposures. The present study investigated the growth inhibition effects of 3 major-use antibiotics, tylosin, lincomycin, and trimethoprim, on 7 algal species from the chlorophyte, cyanobacteria, and diatom groups. Based on median effective concentration (EC50) values, cyanobacteria (EC50 = 0.095-0.13 μmol/L) were found to be the most sensitive group to lincomycin followed by chlorophytes (EC50 = 7.36-225.73 μmol/L) and diatoms (EC50 > 225.73 μmol/L). Cyanobacteria were also the most sensitive group to tylosin (EC50 = 0.09-0.092 μmol/L), but, for this compound, diatoms (EC50 = 1.33-5.7 μmol/L) were more sensitive than chlorophytes (EC50 = 4.14-81.2 μmol/L). Diatoms were most sensitive to trimethoprim (EC50 = 7.36-74.61 μmol/L), followed by cyanobacteria (EC50 = 315.78-344.45 μmol/L), and chlorophytes (EC50 > 344.45 μmol/L) for trimethoprim. Although these results partly support the current approach to regulatory environmental risk assessment (whereby cyanobacterial species are recommended for use with antibiotic compounds), they indicate that for some antibiotics this group might not be the most appropriate test organism. It is therefore suggested that environmental risk assessments consider data on 3 algal groups (chlorophytes, cyanobacteria, and diatoms) and use test species from these groups, which are consistently found to be the most sensitive (Pseudokirchneriella subcapitata, Anabaena flos-aquae, and Navicula pelliculosa). Environ Toxicol Chem 2016;35:2587-2596. © 2016 SETAC.

2008. Relative sea-level change and postglacial isostatic adjustment along the coast of south Devon, United Kingdom. ABSTRACT: Previous sea-level studies suggest that southwest Britain has the fastest subsiding coastline in the United Kingdom, but tide-gauge data, GPS and gravity measurements and geophysical models show little evidence of anomalous subsidence in this region. In this paper we present 15 new sea-level index points from four coastal barrier systems in south Devon. Eight are from compaction-free basal sediments and others were corrected for autocompaction. Our data suggest that relative sea level along the south Devon coastline has risen by 21 AE 4 m during the past 9000 years. Sea-level rise slowed during the middle and late Holocene and a rise of 8 AE 1 m has occurred since ca. 7000 cal. yr BP. Anomalous ages for many rejected points are attributed to sediment reworking during barrier transgression. The relative sea-level history during the early and middle Holocene shows a good fit with geophysical model predictions, but the geological and modelled data diverge in the later Holocene. Unlike the geophysical models, sea-level index points cannot differentiate between late Holocene relative sea-level histories of south Devon and southwest Cornwall. It is suggested that this discrepancy can be resolved by obtaining additional high-quality sea-level index points covering the past 4000 years.

Bed roughness is an important control on ice-stream location and dynamics. The majority of previous bed roughness studies have been based on data derived from radio-echo sounding (RES) transects across Antarctica and Greenland. However, the wide spacing of RES transects means that the links between roughness and flow are poorly constrained. Here, we use Digital Terrain Model/bathymetry data from a well-preserved palaeo-ice stream to investigate basal controls on the behaviour of contemporary ice streams. Artificial transects were set up across the Minch Palaeo-Ice Stream (NW Scotland) to mimic RES flight lines over Institute and Möller Ice Streams (Antarctica). We then explored how different data-resolution, transect orientation and spacing, and different methods, impact roughness measurements. Our results show that fast palaeo-ice flow can occur over a rough, hard bed, not just a smooth, soft bed, as previous work has suggested. Smooth areas of the bed occur over both bedrock and sediment covered regions. Similar trends in bed roughness values were found using Fast Fourier Transform analysis and standard deviation methods. Smoothing of bed roughness results can hide important details. We propose that the typical spacing of RES transects is too wide to capture different landform assemblages and that transect orientation influences bed roughness measurements in both contemporary and palaeo-ice-stream setting.

The occurrence of antibiotics in surface waters has been reported worldwide with concentrations ranging from ng L -1 to low lg L -1 levels. During environmental risk assessments, effects of antibiotics on algal species are assessed using standard test protocols (e.g., the OECD 201 guideline), where the cell number endpoint is used as a surrogate for growth. However, the use of photosynthetic related endpoints, such as oxygen evolution rate, and the assessment of effects on algal pigments could help to inform our understanding of the impacts of antibiotics on algal species. This study explored the effects of three major usage antibiotics (tylosin, lincomycin, and trimethoprim) on the growth and physiology of two chlorophytes (Desmodesmus subspicatus and Pseudokirchneriella subcapitata), a cyanobacteria (Anabaena flos-aquae), and a diatom (Navicula pelliculosa) using a battery of parameters, including cell density, oxygen evolution rate, total chlorophyll content, carotenoids, and the irradiance-photosynthesis relationship. The results indicated that photosynthesis of chlorophytes was a more sensitive endpoint than growth (i.e., EC 50 derived based on the effects of tylosin on the growth of D. subspicatus was 38.27 lmol L -1 compared with an EC 50 of 17.6 lmol L -1 based on photosynthetic rate), but the situation was reversed when testing cyanobacteria and the diatom (i.e., EC 50 derived based on the effects of tylosin on the growth of A. flosaquae was 0.06 lmol L -1 ; EC 50 0.33 lmol L -1 based on photosynthetic rate). The pigment contents of algal cells were affected by the three antibiotics for D. subspicatus. However, in some cases, pigment content was stimulated for P. subcapitata, N. pelliculosa, and A. flos-aquae. The light utilization efficiency of chlorophytes and diatom was decreased markedly in the presence of antibiotics. The results demonstrated that the integration of these additional endpoints into existing standardised protocols could provide useful insights into the impacts of antibiotics on algal species.