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A series of 2-arylamino-1,3-selenazoles was synthesized and their reactivity was studied. The 2-arylamino-1,3-selenazoles and their reaction products were characterized by various spectroscopic methods and X-ray diffraction. In addition, the antimicrobial activity of the 2-arylamino-1,3-selenazoles in a panel of seven bacteria and fungi was examined.

Ischemia-induced biliary tract lesions, called ischemic cholangitis, often lead to strictures of biliary ducts and cholestasis. Causes of ischemic changes of the biliary tract can be found in the arterial blood supply or in the peribiliary capillary plexus. Known examples are thrombosis after transplantation, intraoperative ligation, or the application of chemotherapeutic drugs. Rarely, such changes are due to inflammation of the blood vessels, such as occurs in polyarteritis nodosa or giant cell arteritis. We present a report of a 49-year old man with leucocytoclastic vasculitis after viral infection, influenza vaccination, and antibiotic treatment, leading to florid ischemic cholangitis. We conclude that hypersensitivity vasculitis must be included in the differential diagnosis of cholestasis and cholangitis.

References 1. TOVEY ER, CHAPMAN MD, WELLS CW, PLATTS-MILLS TAE. The distribution of dust mite allergen in the houses of patients with asthma. Am Rev Respir Dis 1981;124:630±635. 2. KEMP TJ, SIEBERS RW, FISHWICK D, O'GRADY GB, FITZHARRIS P, CRANE J. House dust mite allergen in pillows. BMJ 1996;313:916. 3. MCDONALD LG, TOVEY E. Mite allergens in feather and synthetic pillows. Allergy 1999;55:407±408. 4. LUCZYNSKA CM, ARRUDA LK, PLATTS-MILLS TA, MILLER JD, LOPEZ M, CHAPMAN MD. A two-site monoclonal antibody ELISA for the quanti®cation of the major Dermatophagoides spp. allergens, Der p I and Der f I. J Immunol Methods 1989;118:227±235. 5. MCDONALD LG, TOVEY E. The role of water temperature and laundry procedures in reducing house dust mite populations and allergen content in bedding.

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