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Short-term preoperative parenteral administration of (n-3) or (n-6) PUFA-LE significantly alters tissue-specific fatty acid profiles. Preoperative parenteral PUFA-LE supplementation, preferably by marine (n-3) PUFA, ameliorates postoperative intestinal inflammation and dysmotility and could be a promising therapeutic option in POI prophylaxis.

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S100A4 (metastasin 1) belongs to the S100 family of Ca 2+ binding proteins. While not present in most diVerentiated adult tissues, S100A4 is upregulated in the micromilieu of tumors. It is primarily expressed by tumorassociated macrophages, Wbroblasts, and tumor endothelial cells. Due to its strong induction in tumors S100A4 is a promising target for cancer immunotherapy. By reverse immunology, using epitope prediction programs, we identiWed 3 HLA-A1-restricted peptide epitopes (S100A4 A1-1, A1-2, and A1-3) which are subject to human T cell responses as detected in peripheral blood of melanoma patients by means of IFN-ELISPOT and cytotoxicity assays. In addition, IFN-responses to S100A4 A1-2 can not only be induced by stimulation of T cells with peptideloaded DC but also by stimulation with S100A4 proteinloaded DC, indicating that this epitope is indeed generated by processing of the endogenously expressed protein. In addition, S100A4 A1-2 reactive T cells demonstrate lysis of HLA-A1 + Wbroblasts in comparison to HLA-A1 ¡ Wbroblasts. In summary, this HLA-A1-restricted peptide epitope is a candidate for immunotherapeutical approaches targeting S100A4-expressing cells in the tumor stroma.

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