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PurposeRecent reports indicate that histamine and its novel, high-affinity histamine H receptor (H R) play a role in carcinogenesis, and thus H R signalling has become a focus of increasing interest in the pathogenesis of many cancers. The roles of H R in oral epithelial dysplasia (OED), and oral tongue squamous cell carcinomas (OT SCC) are unknown. The purpose of this study was to assess H R expression in OTSCC patients and in cancer cell lines. MethodsBiopsies taken from OED, OTSCC, and healthy oral mucosa were studied by immunostaining. Primary human oral keratinocytes (HOKs) and two cancer cell lines (HSC-3 and SCC-25) were used for the in vitro studies. Quantitative

The present study suggests that cathepsin G in human atherosclerotic lesions is largely derived from MCs and that activated MCs may contribute to atherogenesis by enhancing LDL retention.

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