SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide… 219 INTROduCTION Renovascular hypertension caused by renal artery stenosis (RAS) accounts for 3-5% of all cases of hypertension. It is considered that RAS can lead to glomerular ischemia and secondary blood pressure rise resulting from the renin-angiotensin-aldosterone system activation. Disturbed auto regulatory mechanisms may also play a key role in the development of hypertension because of the renal blood flow reduction and the increase in inter vascular fluid
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