SNP rs198389 (T‑381 C) polymorphism in the B‑type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension

Abstract

SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide… 219 INTROduCTION Renovascular hypertension caused by renal artery stenosis (RAS) accounts for 3-5% of all cases of hypertension. It is considered that RAS can lead to glomerular ischemia and secondary blood pressure rise resulting from the renin-angiotensin-aldosterone system activation. Disturbed auto regulatory mechanisms may also play a key role in the development of hypertension because of the renal blood flow reduction and the increase in inter vascular fluid

Association of brain natriuretic peptide gene polymorphisms with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its mechanism

“…A study by Zhang et al [ 8 ] showed that the BNP gene SNP loci rs198389 and rs198388 are associated with the genetic susceptibility to congenital heart disease. Poreba et al [ 9 ] showed that the SNP at the rs198389 site of the BNP gene is associated with the development of atherosclerotic lesions in the renal artery. In addition, Fox et al [ 10 ] studies showed that the rs198389, rs6668352, and rs198388 SNP sites of the BNP gene were associated with ventricular dysfunction (VnD) after primary coronary bypass surgery.…”

Natriuretic Peptides: Molecular biology, Pathophysiology and Clinical Implications for the Cardiologist

“…BNP genetic variants have also been associated with a modest effect in Type 2 diabetes susceptibility [48] and renal artery stenosis in patients with atherosclerotic renovascular hypertension [49].…”

Relationship Between the Brain Natriuretic Peptide (BNP) Level and Remission of Diabetic Nephropathy with Microalbuminuria: A 3-Year Follow-Up Study

“…In nondiabetic subjects, there is no such effect of HbA1c, and high BNP is a predictor of progression of albuminuria [8]. Another reason of the predictive effect of low BNP on diabetic nephropathy might also be associated with genetic variation of BNP, since a single nucleotide polymorphism of BNP may be related to a low BNP level and reduced renal artery stenosis [43]. On the other hand, HbA1c also had a significant effect on albuminuria ( • ▶ Table 2, 3), but did not show a significant effect on remission of diabetic nephropathy ( • ▶ Fig.…”