[9220][9221] previous notion about the key interactions responsible for the formation of specific mitomycin C-DNA m o n o a d d~c t s .~~ These results may provide a molecular basis for future drug design. Currently studies are in progress to determine the specific site of drug modification and the consensus bonding sequences for lb-f and to model the binding process for select mitomycins to aid in identifying the specific interactions responsible for the sequence selectivity.

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The synthesis, stability and hydrocyanation catalytic activity of nickel(0) complexes of the diphosphite 1 derived from 2,2'-biphenol are described; the X-ray crystal structures of the ligand 1 and its platinum(0) complex 2b are reported.

The phosphine P(CH20H)3 forms water soluble complexes of the type [M{P(CH20H)3}4] (M = Pt, Pd, or Ni) which are catalysts for the addition of PH3 t o CH20 and the Pt complex is readily protonated by water; the crystal structure of the Pd complex is also described.

A feature of Peter Kollman's research was his exploitation of the latest computational techniques to devise novel applications of the free energy perturbation method. He would certainly have seized upon the opportunities offered by massively distributed computing. Here we describe the use of over a million personal computers to perform virtual screening of 3.5 billion druglike molecules against protein targets by pharmacophore pattern matching, together with other applications of pattern recognition such as docking ligands without any a priori knowledge about the binding site location.