sTREM-1 and PGLYRP1 are elevated in CKD patients with poor oral health and positively correlate with the number of active periodontal pockets, following oral infection therapy. Moreover, they positively correlate with MMP-8 and IL-1β. Hence, salivary TREM-1- PGLYRP1 axis could be useful as diagnostic marker for oral infection within CKD patients.
Risk of death was higher among patients with diabetic nephropathy. The deceased had fewer teeth and more oral infections. However, indices used failed to show independent association with survival.
This study confirms the importance of treating oral infectious foci at the predialysis stage in order to prevent adverse outcomes after kidney transplantation.
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