Objectives The aim of this study was to compare the pattern of secretion and the expression
of mucin glycoprotein-2 (MG2) and lactoferrin in individuals with or without
periodontitis. Material and Methods Five individuals with aggressive periodontitis (APG), 5 with generalized chronic
periodontitis (CPG) and 5 without periodontitis (CG) were enrolled after informed
consent. Non-stimulated and stimulated submandibular and sublingual saliva was
collected and samples analyzed by Western blot probed with specific antibodies.
Results Stimulated and non-stimulated salivary flow rates did not differ among groups.
Western blot analysis revealed that stimulation led to: an increase in MG2
expression in all groups, and to lactoferrin expression in APG and CPG. In
non-stimulated saliva, CG exhibited the highest expression of both glycoproteins.
In stimulated saliva, CG exhibited the highest expression of MG2, whereas APG the
highest of lactoferrin. Conclusions The pattern of secretion of MG2 and lactoferrin in health and disease is complex.
Although the present study analyzed samples from a limited number of participants,
the reduced expression of MG2 and lactoferrin in APG and CPG under non-stimulated
condition, the predominant circumstance of salivary secretion during the day,
suggests that these salivary constituents may play a role in the etiopathogenesis
of these diseases.
The radicular tissue of the apical third of the incisors with ARR showed greater root GV (p < .05) than that of the incisors without ARR. Supra-apical alveolar bone exhibited greater GV in the incisors without ARR than incisors with ARR (p < .05). Root GV was not associated with root protection, but rather seemed to have facilitated the process of resorption. The GV of the lingual bone was associated with a higher progression of ARR in the incisors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.