Cardiovascular effects of the linalool-rich essential oil of Aniba rosaeodora (here named as EOAR) in normotensive rats were investigated. In anesthetized rats, intravenous (i.v.) injection of EOAR induced dose-dependent biphasic hypotension and bradycardia. Emphasis was given to the first phase (phase 1) of the cardiovascular effects, which is rapid (onset time of 1-3 s) and not observed in animals submitted to bilateral vagotomy or selective blockade of neural conduction of vagal C-fibre afferents by perineural treatment with capsaicin. Phase 1 was also absent when EOAR was directly injected into the left ventricle injection, but it was unaltered by i.v. pretreatment with capsazepine, ondansetron or HC030031. In conscious rats, EOAR induced rapid and monophasic hypotensive and bradycardiac (phase 1) effects that were abolished by i.v. methylatropine. In endothelium-intact aortic rings, EOAR fully relaxed phenylephrine-induced contractions in a concentration-dependent manner. The present findings reveal that phase 1 of the bradycardiac and depressor responses induced by EOAR has a vago-vagal reflex origin resulting from the vagal pulmonary afferents stimulation. Such phenomenon appears not to involve the recruitment of C-fibre afferents expressing 5HT3 receptors or the two chemosensory ion channels TRPV1 and TRPA1 . Phase 2 hypotensive response appears resulting from a direct vasodilatory action.
BACKGROUND AND OBJECTIVES: Cryotherapy and transcutaneous electrical nerve stimulation are physiotherapeutic resources widely used for the treatment of pain, due to their analgesic actions proved by scientific evidence. The concomitant use of these two therapeutic modalities in clinical practice is becoming more and more recurrent, justified by the assumption of boosting the analgesic effect. However, some physiotherapists disagree with this practice and believe that the simultaneous use of cryotherapy and transcutaneous electrical nerve stimulation nullifies its effects. The objective of this study was to carry out a bibliographic review of studies on the effects of the simultaneous use of cryotherapy and transcutaneous electrical nerve stimulation in pain treatments. CONTENTS: We selected articles published between 2006-2018 in the databases Scielo, LILACS, Medline and Pubmed. The selection was based on the crossing of the keywords: transcutaneous electrical nerve stimulation, cryotherapy and analgesia. The final sample consisted of 6 articles. CONCLUSION: The results of the analysis of the selected articles showed that, as already scientifically proved, the effects of cryotherapy and transcutaneous electrical nerve stimulation alone have their analgesic efficacy. However, most of the studies did not demonstrate a significant improvement in pain with the associated use of transcutaneous electrical nerve stimulation and cryotherapy compared to the isolated use of these physiotherapeutic resources, reinforcing the need for further research to elucidate the issue.
Esse artigo aborda a temática da influência dos exames de imagem no prognóstico da insuficiência cardíaca. O objetivo desta revisão é constatar os principais preditores no ecocardiograma, na tomografia computadorizada e na ressonância magnética que possuem relação com o prognóstico da insuficiência cardíaca (IC). Trata-se de uma revisão integrativa da literatura científica a partir de publicações de 2011 a 2021. Foram escolhidas as bases de dados PUBMED, SCIELO e LILACS, usando termos de busca identificados nos Descritores em Ciências da Saúde (DeCS). Os principais preditores do prognóstico relatados nas publicações incluem: a fração de ejeção do ventrículo esquerdo (50% dos artigos), o volume ventricular (40% dos artigos), a pressão de enchimento das câmaras cardíacas (30% dos artigos), a detecção da etiologia (50% dos artigos) e a presença de fibrose (40 % dos artigos), de alterações valvares (30% dos artigos), e de alterações pulmonares (30% dos artigos). Conclui-se que os exames de imagem fornecem informações capazes de predizer o prognóstico dos portadores de IC e que as diferentes modalidades de imagem contribuem na melhora da precisão dos dados, no prognóstico e por consequência, no manejo adequado e promoção da qualidade de vida da pessoa com insuficiência cardíaca.
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