We investigated the relations between plasma concentrations of homocysteine and vitamins B-12 and B-6 and folate, and scores from a battery of cognitive tests for 70 male subjects, aged 54-81 y, in the Normative Aging Study. Lower concentrations of vitamin B-12 (P=0.04) and folate (P=0.003) and higher concentrations of homocysteine (P=0.0009 ) were associated with poorer spatial copying skills. Plasma homocysteine was a stronger predictor of spatial copying performance than either vitamin B-12 or folate. The association of homocysteine with spatial copying performance was not explained by clinical diagnoses of vascular disease. Higher concentrations of vitamin B-6 were related to better performance on two measures of memory (P=0.03 and P=0.05). The results suggest that vitamins (and homocysteine) may have differential effects on cognitive abilities. Individual vitamins and homocysteine should be explored further as determinants of patterns of cognitive impairment.

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Memory for speech in young and elderly adults was studied by varying speech rate and average predictability of prose passages (measured by a "cloze" procedure). Increased speech rate and decreased predictability yielded poorer memory performance on three retention measures (free recall, cued recall, and multiple-choice recognition), confirming passage predictability as a good predictor of empirical difficulty of a speech passage. Older adults recalled less than young adults on all three measures, with increasing speech rates producing special difficulty for the elderly subjects relative to the young. Although there was a suggestion that elderly subjects were less able to take advantage of passage predictability than the young in recall of very rapid speech, neither age group showed an interaction between passage predictability and speech rate. Results are discussed in terms of a simple extension of the complexity hypothesis to speech recall.