An experimental study was conducted to evaluate the effect of vaccines produced in Ethiopia from vaccine strains used worldwide on the transmission characteristics of velogenic Newcastle disease virus field strain after different vaccination schemes. Chickens were vaccinated with Hitchner B1, La Sota or I-2 via the intraocular and intranasal routes. Vaccine and challenge viruses induced high antibody levels, both in inoculated and contact birds. Prime-boost vaccination protected birds against morbidity and mortality and significantly reduced the incidence of viral shedding from chickens compared with single vaccinated and unvaccinated birds. Protection from disease and mortality was correlated with the presence of positive antibody titres (>4 log2) at day of challenge. Most of the unvaccinated and in-contact birds excreted the virus and showed a high level of antibody titres, indicating the high infectivity of the challenge virus. The detection of the challenge virus in most of vaccinated birds demonstrated that the tested vaccination protocols cannot fully protect birds from viral infection, replication and shedding, and vaccinated-infected birds can act as a source of infection for susceptible flocks. The high mortality observed in unvaccinated birds and their contacts confirmed the virulence of the challenge virus and indicated that this field virus strain can easily spread in an unvaccinated poultry population and cause major outbreaks. Progressive vaccinations supported by biosecurity measures should therefore be implemented to control the disease and introduction of the virus to the poultry farms.