Keratoacanthoma (KA) is classically a benign skin neoplasm that occurs on damaged photo. But the relationship between squam cell carcinome and keratoacanthoma is still on. To date, no clinical or histological criteria can confirm the diagnosis. The very different biologic tendency of rapid onset and spontaneous regression seen in typical KAs has led many clinicians and dermatopathologists to view this lesion as a noninvasive benign entity distinct from SCC. Many authors suggest that there is no single histopathological diagnostic criterion to differentiate KA from traditional SCC. We report A cases of a patients with a Keratoacanthoma that behaved as an invasive SCC.
Buschke scleredema (scleredema adultorum) is a rare pathology of unknown cause. It is characterized by sclerodermiform thickening of the cutaneous tissues mostly in the trunk and shoulder areas, with respect of the extremities. Buschke scleredema is sometimes associated with monoclonal gammopathy, diabetes or infections. This skin disease rarely involves other organs mostly the heart, but also the lungs, skeletal muscles, esophagus, parotid glands, liver, spleen, pleurae, and eyes. We report a new observation of scleroderma adultorum in a diabetic patient.
Paget's disease was first described by Sir Paget in 1874 as an eczema-like lesion of the nipple linked to an underlying cancer. This is a rare entity that affects only 1 to 4% of breast cancers. It mainly affects menopausal women with an average age of 62.6 years. No clinical or epidemiological factors are recognized as predisposing to the development of this disease. Clinically, Paget's mammary disease manifests itself as a scaly, thickened, sometimes pigmented, patchy plaque with irregular edges. This lesion can be limited to the nipple or extended to the areola and even to the surrounding skin. In the case of an eczematous lesion, the main differential diagnosis of Paget's disease is nipple eczema. But unilaterality, scalability and lack of response to corticosteroid therapy help to correct the diagnosis. Other differential diagnoses, such as psoriasis, superficial basal cell carcinoma and melanoma, may also be discussed and only histology will confirm the diagnosis. Mastectomy has long been considered the appropriate treatment because of its frequent association with multifocal or multicenter breast cancer. Currently, the majority of teams adopt conservative treatment.
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