Our results confirmed that NCs internalized and changed the expression of selected miRNAs that further enhanced their uptake. The NCs activated both extrinsic, as well as intrinsic apoptotic pathways to induce apoptosis by targeting survivin in cancer cells and cancer stem cells, without inducing any nonspecific nanotoxicity. Apart from inhibiting angiogenesis and stem cell markers, NCs also maintained iron and calcium levels.

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COVID-19 pandemic began in Wuhan, China, in December 2019. Almost 80% of the patients are asymptomatic or mildly symptomatic. About 15% require hospitalization and 5% need intensive care unit (ICU) admission. Cytokine release syndrome (CRS) is a life-threatening illness which has shown promising result with the use of tocilizumab. This case reports the importance of early recognition and appropriate management of this life-threatening illness.

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