A randomised clinical trial to assess maintenance of gingival health by a novel dentifrice containing 0.1%w⁄w o-cymen-5-ol and 0.6%w⁄w zinc chloride Objectives: To assess the ability of 0.1%w ⁄ w o-cymen-5-ol ⁄ 0.6%w ⁄ w zinc chloride dentifrice to maintain gingival health compared to a sodium fluoride control dentifrice. Design: Following a baseline examination, subjects went through a regimen to bring them to a high level of gingival health. This included a professional prophylaxis supported by oral hygiene instruction prior to commencing study treatment. Subjects brushed twice daily for 12 weeks with either the test or control dentifrice. Examinations for gingival inflammation (MGI), bleeding and plaque were performed after 6 and 12 weeks. Results: 224 subjects were included in the efficacy analysis. Relative to the sodium fluoride ⁄ silica control dentifrice group the o-cymen-5-ol ⁄ zinc chloride dentifrice exhibited statistically significant reductions (p < 0.0001) in MGI, bleeding and plaque of 12.3%, 18.5% and 13.2% respectively after six weeks and 38.1%, 37.8% and 24.2% after 12 weeks. Conclusion: The results of the present clinical study demonstrate that the use of the 0.1%w ⁄ w o-cymen-5-ol ⁄ 0.6%w ⁄ w zinc chloride dentifrice over a 12 week period provides a statistically significant benefit in maintaining gingival health compared to a sodium fluoride control dentifrice.

A randomized controlled trial evaluating the efficacy of a 67% sodium bicarbonate toothpaste on gingivitis Abstract: Introduction: In previous studies, toothpastes with high levels of sodium bicarbonate (>50%) have reduced gingival inflammation and oral malodour. This study compared the effects of brushing for 6 weeks with 67% (test group) or 0% (control group) sodium bicarbonate toothpaste on gingival health. Methods: This was a single-centre, single examiner-blind, randomized, controlled, twotreatment, parallel-group study. Eligible subjects (≥18 years) had ≥20 gradable teeth, mild-to-moderate gingivitis, a positive response to bleeding on brushing and ≥20 bleeding sites. The primary objective was to compare the number of bleeding sites following twice-daily use of 67% sodium bicarbonate toothpaste or 0% sodium bicarbonate toothpaste after 6 weeks. Secondary endpoints included Modified Gingival Index (MGI), Bleeding Index (BI) and volatile sulphur compounds (VSC), assessed after 6 weeks. Safety was assessed by treatment-emergent oral soft tissue abnormalities and adverse events. Results: Of 148 patients randomized (74 to each treatment), 66 (89.2%) completed the study in the test group, compared with 69 (93.2%) in the control group. Compared with the control group, the test group had a significant reduction in the number of bleeding sites at Week 6 (absolute difference -11.0 [À14.0, À8.0], P < 0.0001; relative difference -25.4%), together with significant reductions in MGI and BI (both P < 0.0001). Although the median reductions from baseline for VSC were numerically greater in the test group, the difference did not reach statistical significance (P = 0.9701). Conclusions: This 67% sodium bicarbonate toothpaste provided statistically significant improvements in gingival health and bleeding after 6 weeks of use.

Diabetes mellitus is a chronic disease that is present in almost every country around the world. Diabetics are known to suffer more from gingivitis/periodontitis than the general population. The projected increase in the diabetic population will only lead to an increase in oral diseases, such as gingivitis in this population. This study evaluates an Ayurvedic toothpaste for the control of gingivitis in a diabetic population. In vitro and in vivo evaluations were performed on this Ayurvedic toothpaste. The in vitro study used a well known anaerobic biofilm model. In the in vivo clinical studies, diabetic subjects were evaluated for plaque and gingivitis using classical methods. The subjects were also evaluated using traditional Ayurvedic endpoints, namely (gum bleeding), (inflammation), and (sponginess of gums).The results of these evaluations demonstrate that the Ayurvedic toothpaste has antibacterial efficacy against anaerobic bacteria. Its use by diabetic subjects resulted in a reduction in plaque and gingival indices in two separate studies lasting up to 6 months. In addition, there was an improvement in the Ayurvedic endpoints in these clinical studies as well. This study demonstrates that an Ayurvedic toothpaste has a positive oral health benefit in diabetic subjects who suffer from gingivitis.The research reported within demonstrates that this Ayurvedic toothpaste has a positive oral health benefit in diabetic subjects who suffer from gingivitis. It has also shown effectiveness against anaerobic bacteria that are responsible for periodontal infections.