A randomised clinical trial to assess maintenance of gingival health by a novel dentifrice containing 0.1%w⁄w o-cymen-5-ol and 0.6%w⁄w zinc chloride Objectives: To assess the ability of 0.1%w ⁄ w o-cymen-5-ol ⁄ 0.6%w ⁄ w zinc chloride dentifrice to maintain gingival health compared to a sodium fluoride control dentifrice. Design: Following a baseline examination, subjects went through a regimen to bring them to a high level of gingival health. This included a professional prophylaxis supported by oral hygiene instruction prior to commencing study treatment. Subjects brushed twice daily for 12 weeks with either the test or control dentifrice. Examinations for gingival inflammation (MGI), bleeding and plaque were performed after 6 and 12 weeks. Results: 224 subjects were included in the efficacy analysis. Relative to the sodium fluoride ⁄ silica control dentifrice group the o-cymen-5-ol ⁄ zinc chloride dentifrice exhibited statistically significant reductions (p < 0.0001) in MGI, bleeding and plaque of 12.3%, 18.5% and 13.2% respectively after six weeks and 38.1%, 37.8% and 24.2% after 12 weeks. Conclusion: The results of the present clinical study demonstrate that the use of the 0.1%w ⁄ w o-cymen-5-ol ⁄ 0.6%w ⁄ w zinc chloride dentifrice over a 12 week period provides a statistically significant benefit in maintaining gingival health compared to a sodium fluoride control dentifrice.
A randomised clinical trial to assess maintenance of gingival health by a novel gel to foam dentifrice containing 0.1%w⁄w o-cymen-5-ol, 0.6%w⁄w zinc chloride Objectives: To assess the ability of 0.1%w ⁄ w o-cymen-5-ol ⁄ 0.6%w ⁄ w zinc chloride gel to foam dentifrice to maintain gingival health compared to a sodium fluoride control dentifrice. Design: Following a baseline examination, subjects went through a regimen to bring them to a high level of gingival health. This involved a professional dental prophylaxis supported by oral hygiene instruction prior to commencing study treatment. Subjects brushed twice daily for 12 weeks with either the test or control dentifrice. Examinations for gingival inflammation (MGI), bleeding and plaque were performed after 12 weeks. Results: 205 subjects were included in the efficacy analysis. Relative to the sodium fluoride ⁄ silica control dentifrice group the o-cymen-5-ol ⁄ zinc chloride gel to foam dentifrice exhibited statistically significant reductions (p < 0.0001) in MGI, bleeding and plaque of 32.2%, 26.3% and 20.7% respectively after 12 weeks. Conclusion: The results of the present clinical study demonstrate that the use of the 0.1%w ⁄ w o-cymen-5-ol ⁄ 0.6%w ⁄ w zinc chloride gel to foam dentifrice over a 12 week period provides a statistically significant benefit in maintaining gingival health compared to a sodium fluoride control dentifrice.
Objective: To evaluate the novel assessment of gingival contour volume measurement from digital impressions compared with traditional clinical indices (Modified Gingival Index and Bleeding Index) and oral microflora following a dental prophylaxis. Methods: Following baseline examinations and full mouth digital impression using the LAVA TM Oral Chairside Scanner (COS), subjects had one maxillary quadrant and the contra-lateral mandibular quadrant randomly allocated to receive a complete dental prophylaxis. Subjects then brushed twice daily at home using a standard toothpaste. After 1, 2, 4, 6 and 12 weeks gingivitis examinations and digital impressions of the maxillary and mandibular arches were taken. Results: Significant improvements in gingivitis for the prophylaxis versus no prophylaxis quadrants were observed up to six weeks using both the traditional gingivitis indices and the assessment of change in gingival contour volume from the digital impressions. Conclusion: The assessment of changes in gingival contour volume may be a promising technique for the objective and quantitative clinical evaluation of products or procedures used to treat gingivitis. The effects of a dental prophylaxis were demonstrated by both this novel measure and traditional clinical indices. Key words: Digital impressions, gingival contour volume measurementNumerous gingival indices have been utilised over the years for the purpose of studying the relationship between plaque and gingivitis, conducting epidemiology studies and assessment of product efficacy 1 . These indices have been based on assessment of clinical features of gingivitis including oedema, colour, contour, bleeding and gingival crevicular fluid. The limitations of these indices are that they are not quantitative and rely on subjective assessment by a trained examiner using non linear numerical scales (i.e. where a score of 2 does not necessarily indicate twice the severity of a score of 1) and are subject to interexaminer variability 2 . Bleeding indices are often considered to be more objective with greater clinical relevance than assessments of gingival appearance as a measure of gingivitis. However, even this measure has subjective elements which include the angle, depth and pressure applied during probing, all of which can influence the number of bleeding sites observed 3 . Therefore, it is highly desirable to have an objective, quantitative technique for assessing gingival condition. Recently researchers have evaluated the use of imaging techniques to assess gingivitis [4][5][6] . The major limitation of this technique is that it only includes the assessment of the facial surfaces of the anterior teeth. When compared to the entire mouth this accounts for only a small proportion of the sites which are treated, and does not allow for assessment of those areas of the mouth that have higher levels of disease, and are more difficult for the patient to clean to achieve changes in the gingival condition.Rosin et al. 7 investigated the suitability of measuring volume diffe...
Fluoride dentifrices are the most impactful anticaries modality worldwide. While clinical caries trials have not consistently shown the superiority of one formulation over another, these findings using a sensitive in situ caries model indicated that dentifrices containing NaF or AmF as the sole fluoride source provided the greatest remineralization and fluoridation benefits.
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