Proper burn wound management considers patient’s compliance and provides an environment to accelerate wound closure. Sticky hydrogels are conducive to wound management. They can act as a preventive infection patch with controlled drug delivery and diverse surface adherence. A hypothesis-driven investigation explores a bioinspired polydopamine property in a gelatin-based hydrogel (GbH) where polyvinyl alcohol and starch function as hydrogel backbone. The GbH displayed promising physical properties with O–H group rich surface. The GbH was sticky onto dry surfaces (glass, plastic and aluminium) and wet surfaces (pork and chicken). The GbH demonstrated mathematical kinetics for a transdermal formulation, and the in vitro and in vivo toxicity of the GbH on test models confirmed the models’ healthy growth and biocompatibility. The quercetin-loaded GbH showed 45–50% wound contraction on day 4 for second-degree burn wounds in rat models that were equivalent to the silver sulfadiazine treatment group. The estimates for tensile strength, biochemicals, connective tissue markers and NF-κB were restored on day 21 in the GbH treated healed wounds to imitate the normal level of the skin. The bioinspired GbH promotes efficient wound healing of second-degree burn wounds in rat models, indicating its pre-clinical applicability.

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Mosquito born diseases like dengue fever, Chikungunya, malaria, yellow fever, Zika, etc are posing an enormous risk to human population world wide. Various strategies are being employed to control the mosquito including the use of synthetic insecticides. Continuous application of synthetic insecticides results in development of resistance by mosquitoes and environmental health hazards. When the fourth instar larvae of Aedes aegypti were treated with the LC10 concentration of malathion, there was an increase in the protein concentration after 24 hours. On SDS-PAGE there was an increase in the intensity of major protein bands (74 kDa, 78 kDa, and 34 kDa) compared to the control. The major protein the last instar larvae are storage protein like hexamerins and range in molecular weight from 66-85 kDa. The study of alteration in storage protein on exposure to malathion will be helpful in understanding their role in the toxicity and resistance to the insecticide.

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