Introduction: Frozen Section (FS) helps in the typing of cancer – benign or malignant, tumor subtyping, assessment of margin status and lymph node involvement by the tumor preoperatively. Imprint smear (IS) study in place of Frozen section for intraoperative consultations can be conducted in those Institutes where facility of cryostat is unavailable. This study aims to determine the reliability of Imprint smear study done in intraoperative specimens as an alternative to frozen section by correlating with the Histopathological diagnosis. This is a Materials And Methods: retrospective study conducted at the Government Royapettah Hospital, Chennai over a one-year period from January 2020 till December 2020. The results of Imprint smear study in intraoperative specimens were compared with the histopathological results. We studied 96 per operative Results: specimens that included 48 lymph nodes, 23 ovary, 17 breast, 4 soft tissue, 2 thyroid, 1 bone and 1 cervix specimens. The Imprint study results, when compared with Histopathological diagnosis, showed an overall correlation of results for 83 specimens with a sensitivity of 98.60%, specicity of 52.0%, positive predictive value of 67.26%, negative predictive value of 97.38%, accuracy of 75.30% and p-value of 0.00 suggesting statistically signicant association. Based on the above results, wit Conclusion: h higher value of sensitivity and negative predictive value, the cases reported as negative for malignancy in imprint smear can be nalized as negative thereby preventing radical resection for clinically doubtful malignant cases diagnosed as benign lesions. Imprint smear also helps in providing a timely per operative diagnosis of malignancy guiding the operating surgeons for completion of radical surgery and thereby reducing a re-exploration surgery after diagnosing malignancy later in Histological sections. We conclude that an attempt to do imprint smear study should be done at every institution where cryostat facility is not available
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.