The enhanced Mobile Broadband (eMBB) and ultra-Reliable Low Latency Communications (uRLLC) are the two main scenarios of 5 th generation (5G) mobile communication system networks. There is an obvious difference in service requirements between different scenarios. When multi-scenario services coexist in the 5G networks, exploring optimized resource scheduling and allocation strategies become a critical issue. The 5G New Radio (NR) and numerology technologies have been standardized, which lay the foundation for flexible frame structure and adaptive scheduling. In this paper, we propose the self-adaptive flexible transmission time interval (TTI) scheduling (SAFE-TS) strategy in the eMBB and uRLLC coexistence scenario. Machine learning (ML) is applied to achieve flexible TTI scheduling. Moreover, we design the random forest-based ensemble TTI decision algorithm (RF-ETDA) to accomplish the TTI selection for each service. Compared with the existing ML methods, the proposed algorithm has a performance improvement in selecting TTI, especially for the uRLLC services. Then, the TTI selection results will be the basis of system resource scheduling and allocation. The simulation results prove that the proposed SAFE-TS effectively reduce the delay and packet loss rate of the uRLLC services while guaranteeing the eMBB requirements. Therefore, it is highly recommended that flexible TTI scheduling should be applied in the construction of the 5G networks to achieve superior network performances. INDEX TERMS Flexible TTI scheduling, machine learning, delay, control overhead, eMBB, uRLLC.
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