Background/Aim: The mechanisms underlying capsular contracture remain unclear. Emerging evidence supports the inflammation hypothesis, according to which bacteria from an adherent biofilm cause chronic inflammation and collagen deposition on the implant and trigger capsular contracture. Our goal was to evaluate the effect of different types of breast implants on the growth of Staphylococcus aureus, S. epidermidis, and Pseudomonas aeruginosa, which are commonly found in biofilms in infection. Materials and Methods: Bacteria were grown in tryptic soy broth at 37˚C for 2, 6, and 24 h and subsequently incubated for 24 h on 12 shell sections of smooth, nano-, and macrotextured breast implants. After incubation, the solutions were ultrasonicated and bacterial numbers were determined by serial dilution. S. aureus were fixed, washed with phosphate-buffered saline, dehydrated in ethanol, and coated with a platinum film to visualize the presence of biofilms by scanning electron microscopy. Results: The numbers of S. aureus and S. epidermidis attached to the smooth and nanotextured surface implants were significantly lower than those on the macrotextured surface for all incubation times, whereas the number of P. aeruginosa was non-significantly lowest on the nanotextured surface after 24h incubation. Biofilms on smooth and nanotextured implant surfaces showed patchy patterns on scanning electron microscopy in contrast to the continuous pattern detected on macrotextured implants. Conclusion: Nanotextured breast implants may limit bacterial growth and thus prevent capsular contracture.
Background/Aim: The skin protects the body from ultraviolet rays and other external factors. Various studies have been conducted to identify methods to prevent skin aging and damage. To investigate the protective effects of methylsulfonylmethane (MSM), in this study, a hairless mouse model was used. Patients and Methods: Mice divided into Groups B, C, and D were subjected to UVB irradiation for six weeks, and Group A was considered the control. Retinoic acid is a substance that has been proven to have anti-aging properties. Group C was injected with MSM, group D was injected with retinoic acid, and groups A and B were injected with saline. At the end of the experiment, the degree of senescence was confirmed through visual evaluation, histopathological analysis, immunohistochemistry, and elasticity measurement using SEM. Results: After the end of the experiment, the wrinkle score was 0.
BackgroundWe conducted a prospective cohort study to evaluate effective technique for breast reconstruction after partial mastectomy due to breast cancer. Depending on the location of the cancer and the amount excised, what method to employ is often difficult to determine. Here, we present a new technique, using the vertical LD flap, that can be used in all partial mastectomies and can almost hide scarring. We also compare these results to the mini-LD flap. MethodsWe analyzed a total of 50 and 47 patients, who underwent breast reconstruction with the mini-LD flap and the vertical LD flap, respectively. Immediately after cancer excision, work on reconstruction began. The skin flap for vertical LD was designed in a planaria shape, such that it may be hidden as much as possible and minimize bulging during closure, and the LD muscle flap was designed with a sufficient distance in the inferior direction.ResultsOur finding showed that the vertical LD flap group required significantly less total operation time than the mini-LD flap group. While the mini-LD flap resulted in a scar that was difficult to hide, the donor site scar of the vertical LD flap could not be seen easily, and no scar was visible on the back. ConclusionsThe vertical LD flap is capable of all partial breast reconstruction, can reconstruct defects in all breast regions, and requires a rather small volume of the flap. The patients show relatively fast recovery after the operation and high patient satisfaction.
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