Herein
we report a highly para-selective C–H
olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst.
The reaction proceeds under mild reaction conditions with high efficiency
and broad substrate scope, including mono-, di-, and trisubstituted
tertiary, secondary, and primary anilines. The S,O-ligand is responsible
for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally
simple, scalable, and can be performed under aerobic conditions.
Pd(II)-catalyzed
C–H functionalization of nondirected arenes
has been realized using an inexpensive and easily accessible type
of bidentate S,O-ligand. The catalytic system shows high efficiency
in the C–H olefination reaction of electron-rich and electron-poor
arenes. This methodology is operationally simple, scalable, and can
be used in late-stage functionalization of complex molecules. The
broad applicability of this catalyst has been showcased in other transformations
such as Pd(II)-catalyzed C–H acetoxylation and allylation reactions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.