Our results are similar to those previously published-the diagnosis was suspected in only half of the cases. We consider it important that odontogenic cutaneous fistulas be included among the differential diagnosis of cutaneous facial lesions to avoid delaying appropriate treatment.

Pd(II)-catalyzed C–H functionalization of nondirected arenes has been realized using an inexpensive and easily accessible type of bidentate S,O-ligand. The catalytic system shows high efficiency in the C–H olefination reaction of electron-rich and electron-poor arenes. This methodology is operationally simple, scalable, and can be used in late-stage functionalization of complex molecules. The broad applicability of this catalyst has been showcased in other transformations such as Pd(II)-catalyzed C–H acetoxylation and allylation reactions.

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Abstract:The catalytic asymmetric construction of chiral quaternary stereocenters is always a continuous area of research in organic chemistry. In this sense, when a chlorine atom takes part in a quaternary stereocenter, the difficulty of its synthesis increases along with the significance of the resulting products. This is true, not only because of the intrinsic interest of such chlorinated molecules, but also because they are considered as highly valuable chiral building blocks in organic synthesis, as they can be converted to more complexes molecules by a simple S N 2 displacement. Among the different strategies followed to create chlorinated quaternary stereogenic centers, organocatalysis has played a pivotal role during the last decade. In this review, a comprehensive analysis of such organocatalyzed transformations, which are mainly focalized on the the -chlorination of carbonyl compounds, is presented.

An enantioselective anion-binding organocatalytic approach with versatile N,N-dialkylhydrazones (DAHs) as polarity-reversed (umpolung) nucleophiles is presented. For the application of this concept, a highly ordered hydrogenbond (HB) network between a carefully selected CF 3-substituted triazole-based multidentate HB-donor catalyst, the ionic substrate and the hydrazone in a supramolecular chiral ionpair complex was envisioned. The formation of such a network was further supported by both experimental and computational studies, which showed the crucial role of the anion as a template unit. The asymmetric Reissert-type reaction of quinolines as a model test reaction chemoselectively delivered highly enantiomerically enriched hydrazones (up 95:5 e.r.) that could be further derivatized to value-added compounds with up to three stereocenters.