We present the SPICA Coronagraphic Instrument (SCI), which has been designed
for a concentrated study of extra-solar planets (exoplanets). SPICA mission
provides us with a unique opportunity to make high contrast observations
because of its large telescope aperture, the simple pupil shape, and the
capability for making infrared observations from space. The primary objectives
for the SCI are the direct coronagraphic detection and spectroscopy of Jovian
exoplanets in infrared, while the monitoring of transiting planets is another
important target. The specification and an overview of the design of the
instrument are shown. In the SCI, coronagraphic and non-coronagraphic modes are
applicable for both an imaging and a spectroscopy. The core wavelength range
and the goal contrast of the coronagraphic mode are 3.5--27$\mu$m, and
10$^{-6}$, respectively. Two complemental designs of binary shaped pupil mask
coronagraph are presented. The SCI has capability of simultaneous observations
of one target using two channels, a short channel with an InSb detector and a
long wavelength channel with a Si:As detector. We also give a report on the
current progress in the development of key technologies for the SCI.Comment: 22 pages, 10 figure
X irradiation and exposure to high oxygen tension are known to induce lipid peroxidation. The effects of these stresses on hepatic content of metallothionein, which may be involved in the regulation of zinc and copper metabolism, have been studied. The amount of metallothionein in rat liver was increased 11-fold by a high dose of X irradiation (1000 R). Increased metallothionein content (about 15 times) was also observed in liver of rats exposed to high oxygen tension for 3 days.
The tissue copper contents were measured in mutant (hemizygous macular male and homozygous macular female), heterozygous macular female and normal mice. The copper content in kidney and small intestine from 7-day-old mutant and heterozygote were extremely high compared to normal mice, whereas the copper content in other tissues (liver, brain, spleen and serum) was low. Copper content in whole body of mutant mice was extremely low at three stages (18 days gestation, 1 day old, and 7 days old) compared to normal mice with the exception of the mutant fetus at 14 days of gestation. Renal copper contents in the mutant fetus at 18 days of gestation and in the 1-day-old mutant were not changed compared to normal mice, whereas that in 7- and 14-day-old mutant mice was significantly elevated. Hepatic copper content of the mutant mice was extremely low at all stages compared to normal mice. Copper therapy was applied to 7-day-old mutant mice. At 1 day after injection, hepatic copper content in the mutants had increased slightly in comparison with the normal control mice, whereas renal copper content was extremely increased. At 7 days after injection, hepatic copper content in the mutants was decreased greatly in comparison with normal control mice, whereas an increase in renal copper content had remained.
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