Ionic metal−organic frameworks (MOFs) offer a new platform to design and construct complete heterogeneous bifunctional catalytic systems for the chemical fixation of CO 2 with epoxides. Herein, we developed a series of bifunctional pyridinium ionic MOF heterogeneous catalysts (66Pym-RXs and 67BPym-MeI) by the postsynthetic N-alkylation of noncoordinated pyridine sites in porous MOFs. The synergetic catalytic effect of acidic sites with nucleophilic anions in the ionic MOF significantly enhanced the catalytic activity toward the cycloaddition of CO 2 with epoxides to produce cyclic carbonates under cocatalyst-free and solvent-free mild conditions. The catalytic activity of ionic MOFs is easily tuned by the introduction of different alkyl groups into pyridinium cations and halide ions. The 66Pym-iPrI catalyst displayed the highest catalytic performance in terms of the turnover number value for the synthesis of cyclic carbonates. The proposed alternative method provides the means of developing functional N-heterocyclic groups for the new design of bifunctional ionic MOFs as potential heterogeneous catalysts for CO 2 fixation applications.

A number of pre-designed benzoxepine-1,2,3-triazole hybrids were synthesized for the first time using a Cu catalyzed azide-alkyne cycloaddition (CuAAC) strategy. Thus a 10

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Palladium-catalyzed highly regio- and stereoselective 6-exo-dig and 7-endo-dig cyclization of functionalized propargylic compounds has been developed for the synthesis of (E)-4-(isobenzofuran-1(3H)-ylidene)-1,2,3,4-tetrahydroisoquinolines and aze/oxepinoindoles.

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An efficient, highly regio-and stereoselective protocol for the synthesis of tetrasubstituted olefins was developed to take place by a palladium(0)-catalyzed triple domino process. It involves the formation of three new CÀC bonds through double carbopalladation and CÀH activation across 2-bromoaryl alkynyl biaryls/heteroaryls with norbornene. This method is practically simple with broad substrate scope and tolerates a wide range of substituents. The products bearing 9Hpyrrolo[1,2-a]indole motifs reveal intriguing solid state fluorescence properties and thus form a new class of aggregation induced emission (AIE) fluorophores.

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The title compound (I), (E)-2-benzyl-3-(furan-3-yl)-6,7-dimethoxy-4-(2-phenyl-1H-inden-1-ylidene)-1,2,3,4-tetrahydroisoquinoline (C 37 H 31 NO 3 ), was synthesized and structurally characterized by elemental analysis, 1 H NMR and 13 C NMR and single crystal X-ray diffraction. In the compound, the N-containing six-membered ring of the tetrahydroisoquinoline unit adopts a distorted half-chair conformation. In the crystal structure, supramolecular chains mediated by C-H…O contacts along the b-axis are linked into a double layer via C-H…π hydrogen bonds. The resulting double layer stacks along the c-axis without any specific interactions. The molecular geometry was also optimized using density functional theory using (DFT/B3LYP) method with the 6-311G(d,p) basis set and compared with the experimental data. In addition to the optimized geometrical structure, molecular orbital, molecular electrostatic potential (MEP) and chemical reactivity studies of the compound have been investigated by using DFT. The antibacterial activity of the compound for various concentrations were determined against eight test pathogens Bacillus cerus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Acinetobacter baumannii, Staphylococcus epidermidis, Klebsiella pneumoniae and Proteus vulgaris. The results revealed that the compound exhibited good to moderate antibacterial activity.