An interesting electrochemical direct bisarylation of
carbonyls
with indole derivatives to afford the corresponding bis(indolyl)methane
(BIM) derivatives is described. The developed protocol is suitable
for aliphatic, aromatic, and heteroaromatic aldehydes, which react
with various electron-rich and electron-poor indoles to afford the
corresponding BIMs in good to excellent yields. Isatin derivatives
also underwent bisarylation with various indole derivatives under
the influence of current to afford the corresponding BIMs in excellent
yields.
First electricity-promoted, catalyst-free cascade thia-Michael addition and thioacetalization of cyclic enones with thiols are described. The electro-organic protocol was found suitable for both the alkyl as well as aryl thiols as they reacted with a variety of cyclic enones to afford the corresponding tris-sulfane in good to excellent yields. Based on control experiments, it was found that this cascade reaction is chemo-selective involving first thia-Michael addition followed by thioacetalization process.
A metal-free direct C-H selenation of aniline derivatives via an iodine catalysed C-Se bond formation using diselenides as a selenium source at ambient temperature is described. A variety of aniline derivatives underwent regio-selective C-H selenation with different diselenides to afford the corresponding aryl selenoethers in good to excellent yields.
An atom-economical hydrosulfonation of densely functionalized alkenes under catalyst-free conditions is described. Alkenes possessing hydroxy-oxindole moiety underwent hydrosulfonation on treatment with arylsulfinic acids in green media to afford the resulting...
An electricity promoted chemoselective functionalization of alkenes having oxindole moiety with thiols and selenols under the catalyst‐free conditions to afford thioethers and selenoethers in 70–96 % and 90–94 % respectively is described. Substrates bearing electron‐neutral, ‐donating, and ‐withdrawing substituents all were well tolerated under the developed electrochemical reaction conditions.
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