33Background 34 The application of polymeric materials in medical industry has grown drastically in the last 35 two decades due to their various advantages compared to existing materials. The present 36 research work emphases on the sol-gel technique to formulate the polymethyl methyl 37 acrylate/polystyrene/silica composite membrane.
38
Methods
39The characteristic of the composite was investigated through modern state art of 40 instrumentation.
41
Results
42The functional groups attached to the polymer was absorbed by FTIR. The FTIR spectrum 43 confirm that the blend was mixed thoroughly and the formation of unite intimately between 44 the polymers. The membranes were observed by SEM for its surface homogeneity which 45 depends upon the composition of the two blending polymers. The captured SEM images 46 showed the formation of microcracks on the surface, which was evidently controlled by 47 varying the constituent polymer ratios. The prepared blend membranes with 2:1 ratio of 48 PMMA/PS/Si displayed higher water uptake compared to other blended membranes. The 49 composite membranes had good hydroxyl apatite growth in SBF solution. Furthermore, the in 50 vitro cytotoxicity studies carried out by MTT method, using RAW macrophage cells showed 51 that all the samples exhibited excellent cell viability. 52 Conclusion 53 The inflammatory response of composite with equal concentration of PMMA-PS were 54 performed and observed no inflammation in comparison with control and other tested 55 concentrations. 56 Immense research in biomaterials used for hard and soft body tissues replacement and 63 orthopedic applications were constantly increasing during the past few decades[1-5]. 64 Biomaterials, used for this kind of replacement should be inert, bioactive and biocompatible. 65 Based on the type of implant needed, the type of material like metals, alloys, ceramics and 66 polymeric materials can be selected as a suitable biomaterial [6]. Among various kinds of 67 biomaterials, polymeric biomaterials have gained more importance in recent days due to its 68 vast advantages. Moreover, polymeric biomaterials are being used as a replacement of 69 metallic materials (amalgam) due to their added advantage like light weight and tailor made 70 properties[6]. There are several natural polymers like chitosan, cellulose having bioactivity 71 and biocompatibility are used as biomaterials for various wide range of biomedical 72 applications[7, 8]. However, the applications of these natural polymers are limited in terms of 73 its stability and strength. The synthetic polymer is an alternative to natural polymers which 74 may enhance the stability, strength and biocompatibility. These tailor-made properties of 75 synthetic polymers improve its medical and biomedical applications. There is list of synthetic 76 polymers such as polyamides (PAm), polyethylene (PE), polyether ether ketone (PEEK), poly 77 methyl methacrylate (PMMA), polysulfone (PSu), polytetrafluoroethylene (PTFE), 78 polyurethane (PU), and ultra-high molecular weight ...
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