ABSTRACT:A new [1,5]-benzodiazepines (VI) were synthesized by the reaction of ophenylenediamine with 2-chloro-3-acetylquinoline in the presence of tetrabutyl ammonium bromide (TBAB) in short reaction time with excellent yield.
A series of some new[1,5]benzodiazepines has been synthesized using condensation reaction of o-phenelendiamine with different newly synthesized quinolinyl ketones and effect of different aliphatic acids used as a catalyst was studied. Among the catalytic screened aliphatic acid, chloroacetic acid are a versatile catalyst that modify the yield (60-95%) in short reaction time.
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