Synthesis of New [1,5]-Benzodiazepine Derivatives Catalyzed by Various Aliphatic Acids

Abstract

A series of some new[1,5]benzodiazepines has been synthesized using condensation reaction of o-phenelendiamine with different newly synthesized quinolinyl ketones and effect of different aliphatic acids used as a catalyst was studied. Among the catalytic screened aliphatic acid, chloroacetic acid are a versatile catalyst that modify the yield (60-95%) in short reaction time.

In vivo Anticonvulsant and Neurotoxicity Evaluation and Docking Study of Promising Novel [1,5]-Benzodiazepine Derivatives

“…Starting materials were purchased from Aldrich Chemical Company and used without further purification. Compound 2 (Amin et al, 2004;Bhat & Bhaduri, 1986;El-Gaml, 2013;Wright, 1986) was synthesized according to the reported method…”