Methods: Retrospect ive analysis of 47 patients of oral tongue squamous cell carcinoma treated surgically and pathologica lly staged as T2N0 with clear margins. The study period was from March 2004 to March 2011. Treatment outcome was evaluate d in terms of was locoregio nal recurre nce, disease free survival and overall survival. Kaplan Meir survival curves were used for the analysis. The mean follow up period was 28.3 months.Results: Recurrences occurred in 13 out of 47 patients (27.7%). At 5 years the overall survival is 80.5% and disease free survival is 53.9%. Univariate analysis revealed two significant prognost ic predictors for disease free survival: perineural invasion (PNI, p = 0.037) and lymphov ascular invasion (LVI, p = 0.05). This two factors did not have an effect on overall survival (p = 0.717).
Conclusion:In oral tongue cancer (pT2N0), PNI and LVI significantly increased the recurre nce rate without an impact on surviva l. Prospect ive studies with large patient numbers are needed to evaluate this further and to see if adjuvant therapeuti c strategies need to be changed .
Surgical treatment for patients with actinomycosis with head and neck reconstruction should be considered as a reliable treatment option with a good long‐term effect.
45Summary Introduction. In occlusive diseases of carotid arteries may be involved salivary glands which play important role in oral and general homeostasis. Aim of the study. The purpose of this study was histomorphological evaluation of rabbit's salivary glands after regional reduction af arterial circulation and reconstruction of ligated common carotid arteries comparing with normal histological sight. Materials and methods. The experiments were authorized by the Animal Ethics Committee of the Latvian Food and Veterinary Service. 20 male Californian rabbits weighing approximately 3 kg were used. Under intravenous general anesthesia and local anesthesia the ligature of a. carotis communis dextra was done. After 28 days 10 rabbits were sacrificed and samples were taken from all major salivary glands and histological measured acinar dimensions and acinar epithelial cell. For rest 10 rabbits under the general anesthesia were performed revascularization of a. carotis communis dextra. After 28 days the rabbits were sacrificed with intrapulmonal injection of T61. The acini dimensions and acinar epithelial cell diameter in microns in all glands were measured except buccal glands were measured. Results. In ischemic conditions all glands react with decrease of acinar epithelial cell diameter and also diametr of functional unit of salivary gland.After revascularisation reestablishment of acini and secretory epithelial cells was observed. Conclusions. Rabbit's salivary glands have potential to recovery in diminished after ligation of ipsilateral common carotid artery size of acini and secretory epithelium after 4 week ischemia if the blood supply is reestabilished.
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