P.361 Functional activity of rabbit salivary glands in experiment

Stamers, Kaspars; Skaģers, Andrejs; Pilmane, Māra; Pastars, Kalvis; Tomisheva, Nonna; Ratniece, M.

doi:10.1016/s1010-5182(08)72149-8

Cited by 1 publication

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“…In this regard, the New Zealand white (NZW) rabbit has been previously utilized as a translational model to examine salivary gland biology and function [9,10]. Scintigraphic studies have been conducted in NZW rabbits to assess radiation-induced salivary gland injury and to evaluate the efficacy of radioprotective agents such as lidocaine [11,12].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Guided Photoacoustic Imaging of Salivary Gland Hemodynamics in Rabbits

Bolookat,

Vincent-Chong,

Rich

et al. 2024

Photonics

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Xerostomia (severe dry mouth) is a debilitating and often permanent side effect experienced by head and neck cancer patients due to radiation injury to salivary glands. In this study, we evaluated the potential of ultrasound (US)-guided photoacoustic imaging (PAI) to non-invasively assess early changes in salivary gland hemodynamics following radiation therapy (RT). US-guided PAI was performed in New Zealand white rabbits to visualize and quantify the hemoglobin concentration (HbT) and oxygen saturation (%sO2) of parotid glands before and after RT. The imaging findings were validated with histology and sialometry. An early increase in parotid gland HbT and %sO2 was seen following RT. Consistent with the PAI observations, histology of salivary glands revealed dilated blood vessels, along with hemorrhaging and fibrosis. Sialometric analysis confirmed a significant reduction in stimulated saliva secretion in irradiated rabbits compared to controls. Collectively, our findings demonstrate the translational utility of US-guided PAI as a valuable tool for label-free functional imaging of salivary gland hemodynamics in vivo.

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