The expression pattern of sNHE suggested that this protein may be involved in the regulation of sperm motility, and aberration of its expression in sperm may contribute to the pathogenesis of asthenozoospermia.
control of spermatogenesis by specific proteins that require a high degree of regulation, mRNA posttranscriptional regulation is also essential for the regulation of gene expression, growth, and development. In recent years, some studies have indicated that miRNAs, some short endogenous noncoding RNA molecules, play crucial roles in the posttranscriptional regulation of spermatogenesis in humans [6][7][8][9][10][11][12][13][14][15][16] and that miRNAs in seminal plasma might predict the presence of sperm in testicular tissue; 17,18 however, only a few miRNAs have been studied, and the altered miRNA profiles in nonobstructive azoospermia (NOA) need to be further elucidated. Although sperm can be found in some NOA patients through testicular aspiration or microdissection testicular sperm extraction, the majority of these patients are still unable to obtain sperms, which is a major problem for clinicians and has received wide attention from the society in recent years.Therefore, in this study, we used miRNA microarray technology to compare and analyze differential miRNA expression in testicular tissues obtained from NOA and obstructive azoospermia (OA) males, respectively, the latter of which exhibit normal spermatogenesis.
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