Background/aim: This study assessed the histopathological effects of Aloe vera (AV) on penile fractures (PF) formed experimentally in rat model. Materials and methods:Thirty two Wistar adult male rats (220 to 250 g) were used. PF model was created experimentally with a number 15 lancet. After the interventions, all of the rats were randomly and equally divided into 4 groups. In the first group, incision was not closed (group C). In the second group, AV was locally applied onto incision without suturing for three days (group AV). In the third group, the incision line was closed primarily (group PR). In the last group, AV was applied to primary repair region for three days (group PAV). All groups were compared to each other according to presence of fibrosis, inflammation and hyperemia-bleeding.Results: Hyperemia and bleeding were seen in all groups with varying degrees and the difference between groups was insignificant (p=1.000). According to inflammation, there was significant difference between all groups (p=0.031). No significant inflammation was observed in group AV and therefore, group AV had a better score than group PR (p=0.026).In group PAV, inflammation was less seen than group PR, however, the difference was insignificant (p=0.119).According to fibrosis, group AV and group PAV had same fibrosis rates. Fibrosis was observed in 2 (25%) rats in each group. When group PR was compared with group AV and 2 group PAV, there were no significant differences according to cavernosal tissue healing with fibrosis (p= 0.132 and p=0.132, respectively). Conclusion:Local application of AV onto the PF region without closing with suture decreased inflammation in rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.