A number of studies have already been undertaken to investigate involvement of oxyradicals in muscle diseases by means of measurements of oxyradical protective enzymes. We investigated o-tyrosine, which is a biomarker for OH radical damage in vivo, in 10 mdx and 10 control mice. We also measured mitochondrial enzymes in muscle homogenates of 10 mdx and 10 control mice. Mdx mice had significantly elevated values for o-tyrosine, succinat-phenacinmetosulfat oxidoreductase. NADH O2 oxidoreductase and cytochrome C oxidoreductase. Our findings confirm the suggestion that elevated oxyradical production occurs in muscular dystrophies with lack of dystrophin. Furthermore, our results demonstrate that OH radical damage does not impair mitochondrial enzyme activities in the mdx mouse.
Summary:A semi-longitudinal study in 111 healthy school children, 11 years old, was started in May 1976 to evaluate age-related "normal-ranges" of two so-called "routine" tyood parameters during adolescence. Follow-up examinations were performed at one-year intervals until 1982. In this paper growth velocity is described and results of estimations of alkaline phosphatase, inorganic phosphorus (Pj) and total calcium (Ca) are presented and compared with values in the literature.Peak growth velocity in girls (5.94 ± 1.92 cm/year) occurred between 11 and 12 years, in boys (7.73 ± 2.4 cm/year) between the age of 12 and 13 years; from the age of 14 years onwards boys were significantly taller than girls. A strong relationship (p < 0.05) between growth and alkaline phosphatase could be shown throughout the period observed. Alkaline phosphatase activity varied within a wide ränge and reached mean peak values at the age of 11 years in girls (470.9 + 114.8 U/l) and the age of 13 in boys (514.4 ± 135.7 U/l), Afterwards, alkaline phosphatase activity decreased towards adult levels. Inorganic phosphorus constantly decreased in both boys and girls until the age of 16, while from the age of 16 to 17 years a significant increase could be observed in both sexes. Total calcium values showed a significant increase between 12 and 13 years in boys and between 13 and 14 years in girls; after the age of 14 values decreased significantly in both sexes. Our data strongly support the assumption that the known changes of alkaline phosphatase and Pj are mainly due to growth and pfobably secondarily due to sex hormone changes.
Änderungen der alkalischen Phosphatase, des anorganischen Phosphors und des Calciums im Serum gesunder i i-bis 17jähriger Jugendlicher und deren Bezug zum Wachstum
LeitthemaIn den meisten Lehrbüchern der Päd-iatrie wird der Typ-2-Diabetes (T2DM) -wenn überhaupt -nur in dem Sinne erwähnt, dass sich diese Stoffwechselstörung vom Typ-1-Diabetes dadurch unterscheidet, dass die Patienten nicht insulinabhängig sind, jedoch eine gestörte Glukosetoleranz aufweisen, die Krankheit aber meist erst jenseits des 40. Lebensjahres auftritt.
In two girls (14 and 16 years) and one boy (19 years) with PLW-syndrome and pronounced obesity (240, 210 and 77% overweight) endocrine function tests were carried out. Growth hormone secretion was decreased but normalized after reduction of weight. Thyroxin levels as well as basal and TRH stimulated TSH concentrations were normal. HCG application in the boy induced no rise of the normal basal testosterone levels. Oral glucose tolerance test demonstrated an increased stimulation of insulin in two cases, no other symptoms of diabetes mellitus were found. In the LHRH test an insufficient rise of gonadotropins was found. However, after two weeks of pernasal application of an LHRH analogue (D-Leu6-des-Gly10-EA) the gonadotropin stimulation was distinctly improved and onset of puberty was induced in the male patient. These results are indicative of a hypothalamic disturbance in patients with PLW-syndrome.
We present a case of a 11/2-year-old boy with toxic enteritis, consecutive consumption coagulopathy, and sever brain damage. During the acute phase we found high activity of the BB isoenzyme of creatine kinase in cerebrospinal fluid, but not in the serum. Isoenzyme MM could also be found in the spinal fluid (37.9% of the total activity). We conclude that analysis for creatine kinase isoenzymes in spinal fluid is of clinical importance.
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