Changes of Alkaline Phosphatase, Inorganic Phosphorus and Total Calcium in Sera of 11 to 17 Year Old Healthy Adolescents, and their Relationship to Growth

Widhalm, K.; Hölzl, M.

doi:10.1515/cclm.1985.23.11.711

Cited by 8 publications

(8 citation statements)

References 11 publications

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“…A correlation between osteocalcin levels and alkaline phosphatase activities has also been reported in childhood (33). It is now well established that there is a link between alkaline phosphatase activity and sexual maturity (34,35,36,37,38), which was also confirmed by our results.…”

Section: Discussionsupporting

confidence: 91%

Osteocalcin. A biochemical marker of bone turnover during puberty

Kanbur¹,

Derman²,

Şen³

et al. 2002

International Journal of Adolescent Medicine and Health

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During bone remodelling, osteocalcin is produced by osteoblasts and its level increases during the events characterized by rapid bone turnover. Osteocalcin is a bone matrix protein, which is specific for bone metabolism and it is not influenced by metabolic bone disorders. Osteocalcin is an important marker of bone turnover in physiological and pathological conditions. Physiologically, serum osteocalcin was increased in children, particularly during the first year of life and during puberty, when evolution of the concentration was related to rapidity of physical growth. Evidence of a correlation with growth rates comes from the observation that serum osteocalcin levels parallel the height velocity curve, with higher values in childhood and during adolescence, that later fall to adult values. There are previous studies reporting that there is age-and sex-dependent change in serum osteocalcin levels in children and adolescents with a pattern resembling height velocity curves for children and serum osteocalcin elevation coincides with the pubertal growth spurt. These findings demonstrate that pubertal development and sex should be taken into account rather than chronological age when serum levels of osteocalcin are evaluated. In most of the studies relationships among osteocalcin and chronological age and bone age, but not pubertal developmental stage (sexual maturation stage) were investigated. The aim of our study was to determine whether osteocalcin is a useful marker for the pubertal growth spurt period. In this study, osteocalcin levels in male adolescents were examined in relation to their sexual maturation stage and age. According to our findings, the follow up of osteocalcin levels in relation to sexual maturation stages could be a new method to determine the phase of the pubertal growth spurt. An increase or decrease in osteocalcin levels on consecutive measurements may indicate the child's entering accelerated or decelerated stages of the growth spurt, respectively. We emphasize that the follow up of adolescent growth is made by determination of the sexual maturation stage, and not by age. Osteocalcin is a highly specific, reliable and useful marker for evaluation of the growth spurt and is not influenced by nonosseous disorders.

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Section: Discussionsupporting

confidence: 91%

Osteocalcin. A biochemical marker of bone turnover during puberty

Kanbur¹,

Derman²,

Şen³

et al. 2002

International Journal of Adolescent Medicine and Health

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“…The pattern of changes in mean AP associated with chronological age are similar to those reported previously for other cross-sectional samples of well nourished youth (Posen andDoherty 1981, Widhalm andHolzl 1985). When mean AP is calculated within skeletal age groups, however, the adolescent spurt in AP is more clearly defined and more intense, i.e.…”

Section: Discussionsupporting

confidence: 85%

Serum alkaline phosphatase activity and skeletal maturation in Guatemalan adolescents

Himes

Huang

Haas

et al. 1993

Annals of Human Biology

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Serum alkaline phosphatase activity (AP), stature and Tanner-Whitehouse-2 RUS skeletal age (SA) were determined for 873 rural Guatemalan youth and young adults 11-25 years of age. Mean AP decreases systematically with chronological age (CA) in girls, while an adolescent increase in mean AP occurs at 14 years in boys. When mean AP is calculated within SA groups, clear adolescent increases are apparent in girls, peaking at 11 years SA, and at 14 years SA in boys. Correlations between AP and relative skeletal age (SA-CA) decrease systematically from moderately positive at the youngest CA groups to moderately negative at the older ages, crossing zero at the chronological ages of maximum adolescent AP values. Analyses suggest the patterns of mean AP in adolescence follow closely the timing and patterns of growth velocity in stature in each sex, and are only indirectly related to SA as it is a proxy for the maturational timing of the adolescent spurt in stature.

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“…Several studies have suggested that a biochemical marker, namely alkaline phosphatase (ALP) in the blood plasma, might serve as a reliable marker of skeletal development in vertebrates (e.g., Widhalm and Holzl 1985;Price 1993;Dobado-Berrios and Ferrer 1997;de Behr et al 2003). In free-living birds, it has been shown that active bone growth is accompanied by increased activity of ALP in the blood plasma (raptors: Viñuela et al 1991;Dobado-Berrios and Ferrer 1997;Bailey et al 1998;auks: Seiser et al 2000;passerines: Ormerod et al 1991;Tilgar et al 2004aTilgar et al , 2004bstorks: Smits et al 2007).…”

Section: Introductionmentioning

confidence: 99%

The Rate of Bone Mineralization in Birds Is Directly Related to Alkaline Phosphatase Activity

Tilgar¹,

Kilgas²,

Viitak³

et al. 2008

Physiological and Biochemical Zoology

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Recent studies have suggested that a biochemical marker, plasma alkaline phosphatase (ALP), can be used as a general indicator of skeletal development in vertebrate animals. In birds, age-related variation in ALP activity, presumably due to bone formation processes, has been demonstrated, but to date, a direct connection between bone mineralization and enzyme activity has been elusive. In this study, we show that the activity of a bone isoform of ALP (bone ALP) is closely related to the overall rate of skeletal mineralization in nestlings of a small passerine bird, the great tit (Parus major L). Moreover, bone ALP activity predicted the rate of mineralization of leg and wing bones but not that of the skull. Liver isoform of ALP was only marginally related to the overall rate of skeletal mineralization, while no association with the mineralization of long bones was found. We conclude that bone ALP activity in the blood plasma is a reliable biomarker for skeletal mineralization in birds. This marker enables detection of subtle developmental differences between chicks of similar structural size, potentially facilitating the prediction of offspring mid- and long-term survival.

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Changes of Alkaline Phosphatase, Inorganic Phosphorus and Total Calcium in Sera of 11 to 17 Year Old Healthy Adolescents, and their Relationship to Growth

Cited by 8 publications

References 11 publications

Osteocalcin. A biochemical marker of bone turnover during puberty

Osteocalcin. A biochemical marker of bone turnover during puberty

Serum alkaline phosphatase activity and skeletal maturation in Guatemalan adolescents

The Rate of Bone Mineralization in Birds Is Directly Related to Alkaline Phosphatase Activity

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