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Priw~tdoceut und Prosector am anatomischen Institut zu Bern. Hierzu Tafel XXVII, XXVIII u. XXIX. Schon seit mehreren Jahren bin ich mit der Untersuchung der Epithelien im Allgemeinen und der Drtlsen im Speciellen besehaftigt und zwar haupts~tchlich nnter Anwendung der B enda-He i d e n h a i n'schen Eisenh~tmatoxylinmethode, da ich zuniiehst nut die Absicht hatte, die Lags und Anordnung der Kittsubstanz festzustellen, wozu eben die genannte Methode wie keine andere geeignc~ ist. Da es sieh nun herausstellte, dass ausnahmslos alle intercellulitren Sekretgange Kittlinien aufweisen, so lag der Gedanke nahe, mit Hilfe dieser Thatsache zu entseheiden, ob g'ewisse Sekretg~tnge inter-oder intraeelluli~r resp, um die so ahnlieh klingenden Ausdrttcke zu vermeiden, ob sie z wi s ch e nzelliff oder binnenzellig verlaufen. Zu dem Behuf wurde auch die schnelle Golffi-Methode mit Fixation und Naehfiirbung ang'ewandt. Da nun wie bekannt die Eisenhamatoxylinmethode zuffleich mit den Kittlinien aueh die Centralk(irper seh(in zur

Background Treatment of head and neck cancer (HNC) often leads to visible and severe functional impairments. In addition, patients often suffer from a variety of psychosocial problems, significantly associated with a decreased quality of life. We aimed to compare depression, anxiety, fatigue and quality of life (QoL) between HNC patients and a large sample of the general population in Germany and to examine the impact of sociodemographic, behavioral and clinical factors on these symptoms. Methods We assessed data of HNC patients during the aftercare consultation at the Leipzig University Medical Center with a patient reported outcome (PRO) tool named “OncoFunction”. Depression, anxiety, fatigue and QoL were assessed using validated outcome measures including the PHQ-9, the GAD-2, and the EORTC QLQ-C30 questionnaire. Results A total of 817 HNC patients were included in our study and compared to a sample of 5018 individuals of the general German population. HNC patients showed significantly higher levels of impairment in all dimensions assessed. Examination of association between depression, anxiety, fatigue and QoL and clinical as well as sociodemographic variables showed significant relationships between occupational status, ECOG-state, body mass index and time since diagnosis. Conclusions HNC patients suffer significantly from psychological distress. The used questionnaires are suitable for the use in daily routine practice and can be helpful to increase the detection of depression, anxiety and fatigue and therefore can improve HNC aftercare.

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