Beiträge zur Kenntniss einiger Drüsen und Epithelien

Abstract

Priw~tdoceut und Prosector am anatomischen Institut zu Bern. Hierzu Tafel XXVII, XXVIII u. XXIX. Schon seit mehreren Jahren bin ich mit der Untersuchung der Epithelien im Allgemeinen und der Drtlsen im Speciellen besehaftigt und zwar haupts~tchlich nnter Anwendung der B enda-He i d e n h a i n'schen Eisenh~tmatoxylinmethode, da ich zuniiehst nut die Absicht hatte, die Lags und Anordnung der Kittsubstanz festzustellen, wozu eben die genannte Methode wie keine andere geeignc~ ist. Da es sieh nun herausstellte, dass ausnahmslos alle intercellulitren Sekretgange Kittlinien aufweisen, so lag der Gedanke nahe, mit Hilfe dieser Thatsache zu entseheiden, ob g'ewisse Sekretg~tnge inter-oder intraeelluli~r resp, um die so ahnlieh klingenden Ausdrttcke zu vermeiden, ob sie z wi s ch e nzelliff oder binnenzellig verlaufen. Zu dem Behuf wurde auch die schnelle Golffi-Methode mit Fixation und Naehfiirbung ang'ewandt. Da nun wie bekannt die Eisenhamatoxylinmethode zuffleich mit den Kittlinien aueh die Centralk(irper seh(in zur

The three-dimensional microanatomy of the pancreatic duct system in the Japanese monkey, Macaca fuscata, with special reference to fine proximal passages of a high species-specificity

“…These structures augment the apical cell membrane as well as elongate the tight junctions to facilitate the simultaneous transcellular transport of HCO 3 − ions and paracellular movement of Na + ions across the duct epithelium (19,20). The ductal secretory basement membrane (1,8,27). In support of the latter assumption, our SEM observations characterized the monkey pancreatic acini as a simple epithelium in which all the cells have their own basal surfaces.…”

Eukaryotic Flagella: Variations in Form, Function, and Composition during Evolution

“…It is approaching 350 years since cilia or flagella were first described by Antoni van Leeuwenhoek as the 'little legs' on the protists he saw in rainwater using a homemade microscope (Leeuwenhoek 1677), a little over a 100 years since a sensory function was first suggested for the primary cilium (Zimmermann 1898), just over 60 years since the iconic '9+2' arrangement of axonemal microtubules was first predicted by Irène Manton and Bryan Clarke from their analysis by electron microscopy of zoospore ultrastructure in Sphagnum peat moss (Manton and Clarke 1952), and 50 years since Peter Satir and Ian Gibbons began to develop the dynein-dependent sliding filament model as the basis for flagellar and ciliary motility (Satir et al 2014). It is during the last 30 or so years that molecular bases …”

Juvenile nephronophthisis and dysthyroidism: a rare association

“…Endocrine abnormalities as thyroid hormone deficiency have found in joubert syndrome related disorders (JSRD), but thyroid disorders have not been mentioned as extrarenal manifestations of NPHP in the literature review so far [7,8]. The reasons for this hypothesis are that we know primary cilia are present on a wide variety of cell types such as the bile duct, the kidney tubule, the pancreas, the thyroid, smooth muscle cells, neurons, fibroblasts, and chondrocytes [9] and furthermore they were first observed in the renal epithelium and thyroid gland [10,11], perhaps association between NPHP and thyroid disorders can be illustrated via this observation. In children with recessive mutations in the 1, 2, 3 and 4 genes, retinitis pigmentosa occurs in approximately 10% of all affected families without any obvious genotype/phenotype correlation.…”