Administration of tetracosactid into male rabbits, fitted with permanently indwelling jugular catheters, resulted in a rapid rise of plasma corticosteroids and plasma testosterone. Corticosteroid concentrations were significantly elevated at 40 and 60 min and testosterone concentrations 20 min after the iv injection of tetracosactid (2.5, 5.0, and 10.0 \g=m\g/kg body weight), in comparison to pre-treatment levels. Corticosteroid values in plasma were elevated as long as 120 min after tetracosactid injection.In contrast, testosterone levels were lower at 60\p=n-\120min after tetracosactid injection than corresponding pre-treatment values. However, these differences were not significant. At the doses used no tetracosactiddose-dependent corticosteroid or testosterone release could be found; apparently, testosterone release is only dependent upon basal plasma levels but not upon the dose of tetracosactid applied. From these studies it is concluded that tetracosactid may bring about an increase or decrease of testosterone concentration in plasma in the buck depending upon the length of time elapsing between injection of tetracosactid and blood withdrawal.It has been shown that administration of short term ACTH over a period of several days significantly suppresses plasma testosterone in normal adult human males (Sorcini et al. 1963; Rivarola et al. 1966; Beitins et al. 1973;Irvine et al. 1974; Doerr 8c Pirke 1975. This ACTH-induced suppression of testo¬ sterone is apparently not due to an inhibition of luteinizing hormone (Beitins et al. 1973;Irvine et al. 1974;Doerr &· Pirke 1975. According to Doerr 8c Pirke (1976) the similarities between the ACTH-and cortisol-induced sup-
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