Background/Objectives Medical nutrition therapy along with pharmacological interventions as a multidisciplinary approach is required to treat type 2 diabetes mellitus (T2DM). This study evaluated the efficacy of Jackfruit365™ green jackfruit flour as an integral part of daily meal in patients with T2DM. Subjects/Methods This was a randomized, double-blind, placebo-controlled study conducted between May 2019 and February 2020. Patients of either sex aged ≥18 to ≤60 years with a diagnosis of T2DM for >1 year receiving oral antihyperglycemic agents were randomized (1:1) to receive either jackfruit flour 30 g/day (Group A) or placebo flour (Group B) (breakfast and dinner) daily for 12 weeks replacing an equal volume of rice or wheat flour. The primary endpoint was a mean change in glycosylated hemoglobin (HbA1c). Other endpoints were mean changes in fasting plasma glucose (FPG), postprandial plasma glucose (PPG), lipid profile, and body weight. The independent t-test was used to compare changes between the groups. Results A total of 40 patients were enrolled (n = 20 each). A significantly higher reduction in HbA1c was observed in Group A compared to Group B from baseline to week 12 [−2.73 mmol/mol (−0.25%) vs. 0.22 mmol/mol (0.02%), p = 0.006]. The mean change in FPG and PPG was significantly higher in Group A than that of Group B (p = 0.043 and p = 0.001). The continuous glucose monitoring showed decreasing mean blood glucose in 7 days of administration of jackfruit flour meal. Conclusion Patients from Group A had a significantly higher reduction in HbA1c, FPG, and PPG than Group B demonstrating the efficacy of jackfruit flour in glycemic control as medical nutrition therapy replacing an equal volume of rice or wheat flour in daily meal. Clinical trial registry CTRI/2019/05/019417.

Objective Determine the efficacy of probiotics in treating women with symptomatic white discharge per vagina (WDPV), role of oral probiotics in restoring the vaginal flora. Results This is a prospective randomized clinical study done on 50 women with symptomatic WDPV who are attending gynecology outpatient procedures, these patients underwent Grams stain, received antibiotics along with probiotics for a period of 1 week, again reviewed with repeat Grams stain, 50% were in the age group of 21 to 30 years, duration of symptoms was between 1 and 6 months. In 36% of patients, there was improvement in the lactobacilli count from pretreatment to posttreatment in 100% of cases, but the response in terms of symptomatic relief was seen in 82%. The improvement in the lactobacilli count was interpreted using Nugents scoring. Conclusion The combination of probiotic L. rhamnosus GR-1 and L. fermentum RC-14 is not only safe for daily use in healthy women, but it can reduce colonization of the vagina by potential pathogenic bacteria and yeast. How to cite this article Naik K, Avinash, Nusrat H, Krishna L, Kumar R. An RCT for Efficacy of Oral Probiotics in Treatment of Cases with Symptomatic White Discharge per Vagina in Rural Population. J South Asian Feder Obst Gynae 2012;4(3):126-129.

Background and Aim: Long COVID becomes an economic and public health challenge that affects the daily activities and quality of life of millions of COVID-19 survivors. Long COVID symptoms, particularly persistent fatigue, appear to be associated with a chronic state of inflammation. Based on the anti-inflammatory property of Tinospora cordifolia, CelWel has the potential to improve the symptoms of long COVID. The purpose of this study was to assess the efficacy and safety of CelWel in patients with long COVID. Methods: This was a non-randomized, open-label pilot study with 15 COVID-19-infected male and female subjects who had long COVID symptoms. Subjects were given 0.4 mL of the CelWel supplement 4–6 times per day for 14 days. The severity of long COVID symptoms was assessed using the Fatigue Severity Scale Questionnaire (FSSQ) and the Yorkshire COVID-19 Rehabilitation Screening Test (C19-YRS) before and after treatment. In addition, plasma levels of proinflammatory cytokines and chemokines and the post-acute sequelae score of COVID-19 (PASC) were also assessed. Safety parameters such as adverse events, haematology, and serum biochemistry were also evaluated. Results: Results showed that all COVID-19 survivors had higher FSSQ, C19-YRS, and PASC scores along with elevated plasma levels of proinflammatory cytokines and chemokines before treatment. CelWel supplementation for 14 days significantly reduced FSSQ and C19-YRS scores and plasma cytokine and chemokine levels. Furthermore, with CelWel treatment, PASC scores showed a decreasing trend in 11 subjects, while 4 subjects showed a reverse trend. All laboratory safety parameters were within the normal range, and no adverse events were reported during the study period. Conclusion: These findings suggest that the CelWel supplement is a viable and safe option for reducing the severity of symptoms in patients with long COVID.

Background: The liver is responsible for many critical functions within the body. If the liver becomes diseased or injured, loss of those critical functions can cause significant damage to the body. KaraLivTM is a novel herbal formulation which contains a blend of different herbal extract ingredients. The current study tested the safety and efficacy of KaraLivTM versus a placebo control in supporting liver function.Methods: The study is a randomized, double-blind, parallel, and placebo-controlled study. A total of 60 patients were divided into 2 groups of 30 each. One group was given KaraLivTM and the other group was given a placebo for a period of 56 days. Treatment results were assessed by evaluating the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and alkaline phosphatase (ALP) in both groups.Results: The herbal supplement KaraLivTM significantly supported healthy liver function compared to the placebo following the 56 days of treatment. The treatment (KaraLivTM) group showed a statistically significant improvement in assessed liver enzyme levels compared to the placebo group.Conclusions: The all-natural herbal supplement KaraLivTM is a safe and effective product that can significantly help support healthy liver function.