An RCT for Efficacy of Oral Probiotics in Treatment of Cases with Symptomatic White Discharge per Vagina in Rural Population

Kumar, Rita N.; Krishna, Lanka; LNU, Avinash; Naik, K. Sunil; Nusrat, H

doi:10.5005/jp-journals-10006-1193

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…In this study, the diagnosis of BV was considered in case of at least 3 components of 4 Amsel criteria, including gray vaginal discharge, positive Whiff test, vaginal pH more than 4.5, the presence of clue cells (22,23) and the score of 4 to 6 with clue cells or higher than 7 without clue cells, based on the Nugent scoring system (24)(25)(26). The treatment of this study was the removal of all Amsel criteria or remaining of 1 criterion, as well as getting the scores of 0 to 3 or 4 to 6 without clue cells due to Nugent scoring system.…”

Section: Interventionmentioning

confidence: 99%

The Addition of Vitamin C Vaginal Tablets to Oral Metronidazole and its Effect on the Treatment and Recurrence of Bacterial Vaginosis: A Randomized Triple-Blind Clinical Trial

Mohammadalizadeh¹,

Dokhanchi²,

Hakimi³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

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IntroductionVaginitis is an infectious and inflammatory disease that affects vagina and is associated with abnormal vaginal discharge (1). Lactobacilli is the most common vaginal microorganism. The decrease of lactobacilli may lead to symptomatic changes in vagina. Bacterial vaginosis (BV) is the most common vaginitis that is known by a reduction in vaginal lactobacilli and an increased growth of other anaerobic species of bacteria (2). BV can be observed in 64% of women with sexually transmitted infections, 15% to 20% of pregnant women, and 10% to 15% of women who refer to gynecologic clinics (3,4). BV is widespread in different parts of the world and among different ethnicities. For example, it was detected by 5%-15% among Caucasian women and 45%-55% among African and black Americans. It is estimated that the total prevalence of BV around the world is 20%-30%. The prevalence of BV in Iran varies. It is reported by 16% in central, 40% in southern, and 50% in tribes of Iran (among high-risk population) which is a significant value (5-7).BV is a strong risk factor for acquiring and transmission of sexually transmitted diseases, including human immunodeficiency virus (HIV) and pelvic inflammatory disease (8). Moreover, it infects amniotic fluid and fetal membranes and causes premature rupture of membranes during pregnancy and post-partum fever (9,10).The selected treatment of BV is oral metronidazole (11). However, more than half of patients have 2 to 3 recurrences per year (12). BV affects varying degrees of self-confidence and sexual life of women (13). One of the challenges of physicians is to find the effective treatment of BV, because the long-term effectiveness of antibiotics is weak and recurrence is common (13).The aim of BV treatment is to preserve the vaginal pH at 4.5 and lower and to prevent the over growth of pathogens until normal vaginal flora is reconstructed and maintain normal vaginal pH (14,15). The relationship between BV and increased level of vaginal pH has made the use of vagina acidifier materials as an attempt to build an unsuitable area for the growth of pathogens, reasonable (16). One of the effective materials in maintaining vaginal pH lower than 4.5 is vaginal vitamin C; vaginal vitamin C maintains vaginal pH at low range and is effective in treatment of BV through producing lactic acid (17). AbstractObjectives: Bacterial vaginosis (BV) is the most common vaginitis, which is derived from a reduction in vaginal lactobacilli and an increased growth of other anaerobic species of bacteria. Vitamin C can be effective in treatment of BV through the production of lactic acid. The aim of the present study was to determine the efficacy of adding vitamin C vaginal to metronidazole in treatment of BV. Materials and Methods:This study was a triple-blind randomized clinical trial. The study was carried out from July 2015 to November 2015 on 160 women who referred to gynecologic clinic of Mashhad with pure BV. They randomized into intervention and control groups. The intervention group received 500 ...

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Section: Interventionmentioning

confidence: 99%

The Addition of Vitamin C Vaginal Tablets to Oral Metronidazole and its Effect on the Treatment and Recurrence of Bacterial Vaginosis: A Randomized Triple-Blind Clinical Trial

Mohammadalizadeh¹,

Dokhanchi²,

Hakimi³

et al. 2017

International Journal of Women’s Health and Reproduction Scienc

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Prebiotics and Probiotics in Vulvovaginal Infections

Shah¹,

Tandon²,

Purandare³

et al. 2022

Journal of South Asian Federation of Obstetrics and Gynaecology

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Aim: To discuss the role of prebiotics and probiotics in vulvovaginal infections. Background: Depletion of vaginal microflora in healthy women can lead to various vulvovaginal infections (VVIs). Probiotics such as Lactobacilli are used successfully in treatment and prevention of VVIs. Prebiotics are nutrient substrates for probiotics. Review results: Different strains of Lactobacilli possess different activities (pathogen displacement, bactericidal, and immunostimulatory) that are beneficial in women with VVIs. In nonpregnant women, probiotics administration either orally or vaginally improves clinical, mycological cure rate, and also reduces the recurrences in VVIs. In pregnant women also, probiotics are useful for bacterial vaginosis (BV). In pregnant women, it improves glucose metabolism and might be useful in cases with preterm premature rupture of membranes. Conclusion:In VVIs, intravaginal microbial environment is dysregulated. Upregulating this microflora environment with the use of pre-and probiotics, referred as synbiotics, increases treatment success rate and helps in prevention of recurrences. Clinical significance: Probiotic and prebiotic combination can be considered as one of the essential aspects in the management of VVIs.

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An RCT for Efficacy of Oral Probiotics in Treatment of Cases with Symptomatic White Discharge per Vagina in Rural Population

Cited by 2 publications

References 7 publications

The Addition of Vitamin C Vaginal Tablets to Oral Metronidazole and its Effect on the Treatment and Recurrence of Bacterial Vaginosis: A Randomized Triple-Blind Clinical Trial

The Addition of Vitamin C Vaginal Tablets to Oral Metronidazole and its Effect on the Treatment and Recurrence of Bacterial Vaginosis: A Randomized Triple-Blind Clinical Trial

Prebiotics and Probiotics in Vulvovaginal Infections

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