14 Thiophene derivatives (III) are prepared by this new TFAA/H 3PO4-mediated acylation. On the basis of docking studies followed by in vitro assays, (IIIf) is found to be a novel COX-2 inhibitor with balanced selectivity. -(BINDU, P.; NAINI, S. R.; SHANMUKHA RAO, K.; DUBEY, P. K.; PAL*, S.; J. Heterocycl. Chem. 51 (2014) 3, 586-593, http://dx.
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Antimicrobial agents [(IV) and (VI)] are synthesized with 100% e.e. by BF 3-catalyzed three-component one-pot Mannich reaction in good yields. The products are shown to exhibit good to very high potential activity against microbes and significant minimum inhibitory concentration values against Gram positive and Gram negative bacteria. -(CHENNAKESAVA RAO, K.; EASWARAMOORTHI, K.; ARUN, Y.; BALACHANDRAN, C.; MURALIDHARA RAO, K. S.; GOVINDHAN, M.; EMI, N.; PRAKASAM, T.; PERUMAL*, P. T.; Bioorg. Med. Chem. Lett. 25 (2015) 19, 4232-4238, http://dx.
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