ChemInform Abstract: Synthesis of BF3 Catalyzed Mannich Derivatives with Excellent ee from Phenylpropanolamine, Study of Their Antimicrobial Activity and Molecular Docking.
Abstract:Antimicrobial agents [(IV) and (VI)] are synthesized with 100% e.e. by BF 3-catalyzed three-component one-pot Mannich reaction in good yields. The products are shown to exhibit good to very high potential activity against microbes and significant minimum inhibitory concentration values against Gram positive and Gram negative bacteria. -(CHENNAKESAVA RAO, K.; EASWARAMOORTHI, K.; ARUN, Y.; BALACHANDRAN, C.; MURALIDHARA RAO, K. S.; GOVINDHAN, M.; EMI, N.; PRAKASAM, T.; PERUMAL*, P. T.; Bioorg. Med. Chem. Lett. 25… Show more
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