When respiratory signal is not available, it can be derived from the surface electrocardiogram (ECG) with some limitations. This is particularly useful to understand the contribution of respiratory variability in several conditions where there is an increased risk of cardiovascular mortality. ECGderived respiratory signal is also more valuable in situations of 24-h ECG records, where the continuous respiratory signal is not usually available. We have previously shown that respiratory variability in tidal volume significantly increases during standing posture compared to supine posture. In this study, we obtained respiratory signal derived from the ECG in 17 normal adult controls without a history of heart disease and quantified the time of occurrence of peaks and amplitudes or the QRS complex and performed cross-spectral analysis between R-R (interbeat) interval and the QRS-amplitude time series sampled at 4 Hz. Our findings show that the supine QRS amplitude HF power (0.15-0.5 Hz) correlates significantly with the R-R HF power (r (0.62; n(17; p((0.004). However, this was negatively correlated in standing posture (r (−0.5; n(17; p(0.04). While there was a significant decrease of R-R HF power upon standing ( p(0.01), there was a significant increase in QRS amplitude HF power ( p(0.004). These findings indicate that the variability of QRS amplitude behaves differently in standing posture compared to R-R time series and thus the supine QRS amplitudinal changes may reflect more closely, the respiratory variability. These findings are discussed in relation to the increased QRS amplitude variability in conditions such as coronary artery disease and other populations at risk for increased cardiac mortality.
BACKGROUND One of the primary goals in the treatment of obstructive lung disease is to improve the health-related quality of life (HRQL) of patients. In the current cross-sectional study, we have attempted to identify the traditional physiological and clinical parameters that are independent determinants of Health Related Quality of Life (HRQL) in adult patients with moderate-to-severe asthma. MATERIALS AND METHODS This is a cross-sectional study. 89 asthmatic patients who fulfilled the inclusion and exclusion criteria during the allotted study period were enrolled in the study after obtaining their due consent. Diagnosis of asthma and its severity was based on guidelines set by GINA. They were then made to perform spirometer test as per standard guidelines. They were then handed out two questionnaires, junipers asthma quality of life questionnaire and a questionnaire to assess determinants of asthma. The data of the present study was nominal; therefore Pearson's chi-square test was applied. The data was considered statistically significant at 95% confidence interval. The data was analysed using SPSS version 11. RESULTS Mean age of population was 48.25 years with standard deviation of +/-15.64; 26.66% patients having average quality of life and 52.9% patients with good quality of life were using MDI with spacer. Similarly, 85% patients with history of allergy had an average quality of life and both are statistically significant. 43% of patients with moderate obstruction had an average quality of life, though not statistically significant. CONCLUSION From the present study, it was concluded that though most of the parameters other than drug delivery devices and history of allergy when compared with quality of life was statistically not significant. Though the findings were not statistically significant, the data from the study belonged to average-to-poor quality of life. This warrants further study with a larger sample size.
SummaryBackground:Tuberculosis can disguise itself in any form. Endobronchial tuberculosis usually presents in young adults. Endobronchial tumor-like presentation of tuberculosis (EBTB) is very rare and often mistaken as a malignancy. Diagnosis is usually delayed, as clinical and radiological features are non-specific. Direct implantation of tubercle bacilli into the bronchus, or an contiguous spread, leads to EBTB. Bronchoscopic biopsy and culture are the best modality for diagnosis.Care Reports:Clinical and radiological presentations of all cases were similar and one of them had rib erosion on bone scan. All cases were proven to be tuberculosis by histopathology and culturing mycobacterium tuberculosis. All of them are diagnosed as endobronchial tuberculosis, either histopathology or by culture that grew mycobacterium tuberculosis, and were successfully treated with anti-tuberculous treatment alone, without residual scarring.Conclusions:Tuberculosis should be considered in the differential diagnosis of endobronchial mass lesions in the appropriate clinical setting since this is an uncommon presentation for which invasive procedures are needed to establish the diagnosis. Initially, it was mistaken as a malignancy and there was delay in diagnosis and initiation of treatment. Prompt treatment is crucial to avert residual bronchostenosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.