Increased pulse-wave velocity in patients with anxiety: implications for autonomic dysfunction

Yeragani, Vikram K.; Tancer, Manuel E.; Seema, K; Josyulab, Krishnapriya; Desai, Nagaraj

doi:10.1016/j.jpsychores.2005.10.011

Cited by 43 publications

(32 citation statements)

References 58 publications

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“…They found significant negative correlations between the R-R interval high-frequency power and brachial artery pulse wave velocity (r = 0.4−0.65; p = 0.05−0.007). 29) A simple measurement of brachial artery diameter may also have predictive value for cardiovascular risk, and was recently considered to be a marker of vascular function. 30) Additionally, it was previously reported to be affected by modulation of the ANS.…”

Section: Neurogenic Factor-mediated Pathway To the Endotheliummentioning

confidence: 99%

The Relationship between Vascular Function and the Autonomic Nervous System

Amiya

Watanabe

Komuro

2014

Annals of Vascular Diseases

106

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Endothelial dysfunction and autonomic nervous system dysfunction are both risk factors for atherosclerosis. There is evidence demonstrating that there is a close interrelationship between these two systems. In hypertension, endothelial dysfunction affects the pathologic process through autonomic nervous pathways, and the pathophysiological process of autonomic neuropathy in diabetes mellitus is closely related with vascular function. However, detailed mechanisms of this interrelationship have not been clearly explained. In this review, we summarize fi ndings concerning the interrelationship between vascular function and the autonomic nervous system from both experimental and clinical studies. The clarifi cation of this interrelationship may provide more comprehensive risk stratifi cation and a new effective therapeutic strategy against atherosclerosis.

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Section: Neurogenic Factor-mediated Pathway To the Endotheliummentioning

confidence: 99%

The Relationship between Vascular Function and the Autonomic Nervous System

Amiya

Watanabe

Komuro

2014

Annals of Vascular Diseases

106

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“…17 Others are regarded to be more specific, for instance smooth pursuit eye movement dysfunction, which is known to reflect a genetic vulnerability to schizophrenia (eg, ocular motor abnormalities). 15 Autonomic dysfunction associated with decreased vagal and increased sympathetic modulation occurs in various psychiatric conditions such as major depression, 18 anxiety disorders 19,20 or alcohol dependency, and withdrawal. 21,22 Thus, one could assume that autonomic dysfunction is rather less likely to be specific for one disease.…”

Section: Introductionmentioning

confidence: 99%

Autonomic Dysfunction in Unaffected First-Degree Relatives of Patients Suffering From Schizophrenia

Bär

Berger

Metzner

et al. 2010

Schizophrenia Research

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Recent studies revealed cardiac autonomic dysfunction in patients with acute schizophrenia, which appears to be mainly related to reduced vagal and increased sympathetic modulation. To understand the significance of cardiac autonomic function in patients with schizophrenia, we extended these studies to relatives of patients. In this study, we assessed cardiac autonomic modulation in healthy first-degree relatives of patients with schizophrenia (n 5 36) to investigate a putative genetic influence. Data were compared with control subjects matched for age, gender, and physical activity as well as to patients suffering from schizophrenia. First-degree relatives showed an attenuated, yet identical pattern in autonomic dysfunction as patients with decreased vagal modulation of heart rate, decreased baroreflex sensitivity, but no difference in blood pressure variability could be detected. The patients' relatives also showed a similar pattern in regards to QT variability. In addition, the subgroup comparison of offspring vs. siblingsshowedasignificantdifferenceinheartratevariability suggesting a higher degree of heritability in offspring. In conclusion, the pattern of autonomic dysfunction seen in patients and relatives might indicate underlying disease-inherent genetic vulnerability, especially because autonomic parameters are heritable. In addition, these findings may be of value to identify the high-risk group of patients' relatives in regards to serious cardiovascular events so that early preventive measures can be taken.

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“…For instance, both short and long-term complexity measures of heart rate modulation indicating parasympathetic activity have been shown to be reduced in major depression [15,16] or during treatment [17]. Furthermore, a relative decrease of vagal activity has repeatedly been described for anxiety [18,19].…”

Section: Introductionmentioning

confidence: 99%