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Aim and Objective: In the work, we have successfully presented a synthetic route for the synthesis of novel 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one derivatives via one pot multicomponent approach. Materials and Method: Substituted 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one were prepared through cascade three-component condensation of ortho-hydroxyacetophenone, β-ketoester, hydrazine in the presence of pyrrolidine as a catalyst under ethanol reflux conditions. Results: A series of novel 2',4'-dihydrospiro[chroman-2,3'-pyrazol]-4-one have been synthesized through a facile strategy. These structures of newly synthesized derivatives were determined by 1H, 13C NMR, HRMS and CHNS analysis. Conclusion: We have achieved the one-pot, three-component synthesis of highly substituted pyrazole spirochromanones in presence of pyrrolidine as a catalyst under ethanol reflux conditions. Using different types of aliphatic and aromatic β-ketoesters, o-hydroxyacetophenone derivatives and different kinds of hydrazine derivatives as building blocks, we could construct novel libraries of substituted pyrazole spirochromanones that make this method suitable for combinatorial and parallel synthesis in drug discovery.

A new class of phosphorus macrocycles were synthesized from 2-[(E)-2-2 [(hydroxymethyl) phenyl] imino ethylidene) amino] phenyl methanol 1 with various phenylphosphorodichloridates, phenyldichlorophosphine, and ethyldichlorophosphite in the presence of triethylamine at 0-10 C under N 2 atmosphere in THF. All the title compounds were confirmed by analytical and spectral data (IR, 1 H-, 13 C-, 31 P-NMR, and mass). The title compounds exhibited promising anti-oxidant activity.

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Synthesis and Antioxidant Activity of Novel 15-Alkyl/Aryl-13,17-dihydro-15λ 5 -dibenzo[e,k][1,3,7,10,2]dioxadiazaphosphacyclotridecin-15-selones/thiones/ones. -The novel 13-membered P-heterocycles exhibit promising antioxidant activities. -(NAIDU, K. R. M.; KUMAR, M. A.; DADAPEER, E.; BABU, K. R.; RAJU*, C. N.; GHOSH, S. K.; J. Heterocycl. Chem. 48 (2011) 2, 317-322, http://dx.doi.org/10.1002/jhet.556 ; Dep. Chem., Sri Venkateswara Univ., Tirupati 517 502, India; Eng.) -R. Staver 33-184