Green chemical multicomponent approach for the synthesis of C3-pyranopyrazole-substituted coumarins

One-Pot Access to Diverse Functionalized Pyran Annulated Heterocyclic Systems Using SCMNPs@BPy-SO3H as a Novel Magnetic Nanocatalyst

“…The synthetic strategy to prepare pyranopyrazole derivatives includes utilization of one-pot four-component condensation of hydrazine hydrate, aldehyde, ethyl acetoacetate, and malononitrile. Some catalysts have been utilized to perform this reaction, such as: DABCO [30], meglumine [31], alumina [32], ionic liquid [33], isonicotinic acid [34], triethylamine [35][36], morpholine triflate (MorT) [37], Ba(OH)2 [38], glycine [39], Fe3O4@SiO2-HMTA-SO3H [40], per-6-amino-βcyclodextrin (per-6-ABCD) [41], triethylamine [42], cetyltrimethyleammonium chloride (CTACl) [43], urea [44], -Cyclodextrinepichlorohydrin [45], molecular sieves [46], and SnO2 quantum dots [47]. Recently, a one-pot three-component condensation of 4-hydroxycoumarin, malononitrile, and different aryl aldehydes have been reported for the construction of substituted pyrano[3,2-c]coumarins using various catalytic systems, such as: hexadecyltrimethyl ammonium bromide [48], nanoparticles [49], (DAHP) [50], ionic liquids [51], MGO [52], Mg/La mixed metal oxides [53], nanosilica [54], and H6P2W18O62.18H2O [55].…”

Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

“…In accordance with the increasing need to develop new and simple methods to prepare this biologically active sulfoxide bearing heterocyclic compounds [12][13][14][15][16][17]. Since few years onwards, our laboratory actively engaged with synthesis of different biologically active nitrogen and oxygen heterocyclic molecules by employing green chemical multicomponent approaches [18][19][20][21][22][23][24]. In the continuation of these efforts recently our group has developed novel methodology for synthesis of c]pyrazole-5-carboxylate (5a-q): Mixture of ethyl 3-oxo-5-(phenylthio)pentanoate (1) (385 mg, 0.153 mmol), hydrazine (2) (81 mg, 0.153), benzaldehyde (3a) (172 mg, 0.153 mmol), 1-(2-ethoxy-2-oxoethyl)pyridiniumylide (4) (272 mg, 0.153 mmol), 0.1 equivalents of trimethylamine (16 mg, 0.015 mmol) were refluxed in EtOH (5mL).…”