Herein, we present an environmentally benign method capable of mineralization and deposition of nanomaterials to introduce antibacterial functionalities into cotton fabrics under mild conditions. Similar to the way in which many naturally occurring biominerals evolve around the living organism under ambient conditions, this technique enables flexible substrates like the cotton fabric to be coated with inorganic-based functional materials. Specifically, our strategy involves the use of long-chain polyamines known to be responsible in certain biomineralization processes, to nucleate, organize, and deposit nanostructured ZnO on cotton bandage in an aqueous solution under mild conditions of room temperature and neutral pH. The ZnO-coated cotton bandages as characterized by SEM, confocal micro-Raman spectroscopy, XRD, UV-DRS, and fluorescence microscopy demonstrate the importance of polyamine in generating a stable and uniform coating of spindle-shaped ZnO particles on individual threads of the fabric. As the coating process requires only mild conditions, it avoids any adverse effect on the thermal and mechanical properties of the substrate. Furthermore, the ZnO particles on cotton fabric show efficient antibacterial activity against both gram-positive and gram-negetive bacteria. Therefore, the developed polyamine mediated bioinspired coating method provides not only a facile and "green" synthesis for coating on flexible substrate but also the fabrication of antibacterial enabled materials for healthcare applications.

Herein we demonstrate a bioinspired method involving macromolecular assembly of anionic polypeptide with cationic peptide-oligomer that allows for in situ encapsulation of antibiotics like tetracycline in CaCO3 microstructure. In a single step one-pot process, the encapsulation of the drug occurs under desirable environmentally benign conditions resulting in drug loaded CaCO3 microspheres. While this tetracycline-loaded sample exhibits pH dependent in vitro drug-release profile and excellent antibacterial activity, the encapsulated drug or the dye-conjugated peptide emits fluorescence suitable for optical imaging and detection, thereby making it a multitasking material. The efficacy of tetracycline loaded calcium carbonate microspheres as pH dependent drug delivery vehicles is further substantiated by performing cell viability experiments using normal and cancer cell lines (in vitro). Interestingly, the pH-dependent drug release enables selective cytotoxicity toward cancer cell lines as compared to the normal cells, thus having the potential for further development of therapeutic applications.

No abstract

Fused pyrimidine derivatives R 0515Synthesis Leading to Novel 2,4,6-Trisubstituted Quinazoline Derivatives, Their Antibacterial and Cytotoxic Activity Against THP-1, HL-60 and A375 Cell Lines.-Twelve 2,4,6-Trisubstituted quinazoline derivatives of type (V) are prepared and screened for their antibacterial and cytotoxic effects against the title cell lines. Derivative (Vd) exhibits the highest activity against THP-1 and HL-60 cell lines, whereas (Va) and (Vb) show moderate activity. -(CHANDRIKA, P. M.; YAKAIAH, T.; NARSAIAH*, B.; SRIDHAR, V.; VENUGOPAL, G.; RAO, J. V.; KUMAR, K. P.; MURTHY, U. S. N.; RAO, A. R. R.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 6, 840-847; Fluoroorg. Div., Indian Inst. Chem. Technol., Hyderabad 500 007, India; Eng.) -M. Bohle 43-171

No abstract

No abstract

No abstract

No abstract