OBJECTIVE The optimal adjuvant management for atypical meningiomas remains controversial. The aim of this study was to review long-term outcomes to identify potential prognostic factors for disease progression. METHODS From August 1992 to August 2013, 70 patients with atypical meningioma were treated at the authors' institution. Pathology revision was performed based on WHO 2007 criteria. Patients with multiple tumors, neurofibromatosis Type 2, or inadequate imaging follow-up were not eligible. The authors performed pre- and postoperative serial measurements of tumor volume from MRI. Age, sex, tumor location, bone involvement, brain invasion, mitotic figures, preoperative disease volume, extent of resection, tumor growth rates, use of adjuvant postoperative radiation therapy (PORT), and residual tumor volume at the time of radiation therapy (RT) were assessed by univariate and multivariate analysis to determine their potential impact on disease progression. RESULTS Forty patients (57%) underwent gross-total resection (GTR) and 30 (43%) underwent subtotal resection (STR). PORT was delivered to 12 patients (30%) with a GTR and in only 4 (13%) with an STR. The 5-year progression-free survival (PFS) rate for patients in the GTR group with or without PORT was 100% and 54.1%, respectively (p = 0.0058). PFS for patients in the STR group with or without PORT was 75% and 0%, respectively (p = 0.0026). On multivariate analysis, STR and PORT were the only independent significant prognostic factors for disease progression with hazard ratios of 5.4873 (95% CI 2.19-13.72, p = 0.0003) and 0.0464 (95% CI 0.0059-0.364, p = 0.0035), respectively. Based on Youden's index statistic, a cutoff residual tumor volume of more than 8.76 cm at the time of RT was associated with worse PFS (13.6% vs 56%, p = 0.0079). Before receiving RT, the median relative and absolute growth rates and tumor doubling time for patients were 124.2%/year, 4.8 cm/year, and 1.67 years, respectively. These indices changed after RT to 0.245%/year, -0.09 cm/year, and -0.005 year, respectively (p < 0.05). CONCLUSIONS In atypical meningioma, the use of PORT is associated with improved PFS even in patients who undergo GTR. Patients with residual tumor volume larger than 8.76 cm have an increased risk of disease progression and should be considered for early RT.
Objective: The present study was undertaken to study the variations in the Peak Expiratory Flow Rate (PEFR) with various factors like age, height, weight, body surface area (BSA) and the Body Mass Index (BMI) in healthy women of the Malwa region of Punjab, India. Material and Methods:Three hundred healthy women who were aged 20-50 years were selected from the Malwa region of Punjab and their PEFRs were determined. The influences of age, height, weight, BSA and BMI on the PEFR were studied. The PEFR test was performed by using a mini Wright Peak Expiratory flow meter. Results:The mean PEFR of the women of the Malwa region of Punjab was found to be 395.87 ± 56.81 litres/minute. The PEFR increased with an increase in the age, height, weight and the BSA, but it decreased with an increase in the BMI. Conclusion:This study generated the preliminary values of PEFR for the women of the Malwa region of Punjab, India.
The problemAdministration, in general, is conceived as the necessary activities ofpersonne1 in an organization who are charged with ordering, forwarding and facilitating the associated efforts of a group of individuals brought together to achieve certain pre-decided objectives. Administration in a community development programme is meant for providing a suitable form of organization with efficient personnel management, to plan and execute the programme with proper budgeting, to ensure co-ordinated approach of different development departments, to give proper direction and supervision and to report and evaluate the activities for reconsideration.The present study was planned and conducted in the year 196I -62 to analyse the community development administration and to detect the barriers and conditions in the operational and administrative structure which might be impairing the attainment of a programme's objectives.The study aimed at analysing the various aspects of community development administration, viz., organization, personnel management, planning and execution, budgeting, direction and supervision, co-ordination, reporting and evaluation, at village, block and district levels. The research area was Gorakhpur Division of Uttar Pradesh comprising the four districts -Azamgarh, Basti, Deoria and Gorakhpur.! Two blocks from each district -one an outstanding and the other an ordinary block -were selected based on the preceding year's block reports available at the district headquarters.The research techniques used in this study were structured studies with questionnaires, unstructured studies, content analysis of the records, contextual studies and personal discussions. The questionnaire method was however the most important single method used.The respondents of the study were village level workers, assistant development officers, district technical officers, and administrative officers (block development officers and district planning officers). Their distribution has been Shown in Table I below.
One of the cardinal findings of the renal disease is proteinuria, which appears in the early phase of kidney disease and is very important in diagnosis, prognosis and decision-making in treatment process and results of treatment. Besides this abnormal protein fractions are commonly observed in renal disorder. Serum will be collected for protein electrophoresis and Quantization of each fraction was done. So the present study is designed to find the role of serum protein electrophoresis in renal disorder patients.The aim of the present study was to study protein electrophoresis pattern in various renal disorders.The present study was a hospital-based observational study. The study was conducted over a period of 1 year on 50 patients with renal disorder of either sex visiting the OPD/IPD of Medicine department of Guru Gobind Singh Medical College and Hospital Faridkot. SDS Page electrophoresis was done to evaluate serum proteins in the patients with renal disorders.The results of the study showed the comparison of protein content in patients of NS and ESRD at p<0 Albumin(t=3.86), α1 Globulin(t=6.18), t=-2.76)>0.05). The Comparison of protein content in patients of NS and CKD at p<0 Albumin(t=5.42), α1 Globulin(t=3.38)>0.05).The present study concluded that serum protein fractions are altered in various renal disorders. Protein electrophoresis should be used in addition to other renal markers for better monitoring of the disease progression.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.