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The effects of three compounds, digitolutein (1), rubiadin 1-methyl ether (2) and damnacanthal (3) extracted from the stem bark and the roots of Morinda lucida Benth. on the growth of Plasmodium falciparum in vitro were investigated. The number of parasites (schizonts) decreased significantly in a dose-dependent manner, and 100% of inhibition was obtained with 30 to 40 micrograms of each compound tested. The IC50 values were calculated.

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Extracts obtained from the leaves of Annona muricata, Ficus polita, LuJa aegyptiaca, Momordica charantia and Newbouldia laevis and from the twigs and leaves of Moringa pterygospenna were screened for antimalarial action against Plasmodium falciparum cultured in vitro. AU six extracts were found to inhibit the growth of P . falciparum in a dose-dependent manner. The IC, values vaned from 12.6 pg/mL for Newbouldia laevis to 68.4 pg/mL for Momordica charantia.